DIBAC-GGFG-NH2CH2-Dxd

Name: DIBAC-GGFG-NH2CH2-Dxd
Brand: MedChemExpress
SKU: HY-147363
Rating: 4.5 (0 reviews)

Cat. No.: HY-147363 Pureza: 98.57%: Ficha de datos
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DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DIBAC-GGFG-NH2CH2-Dxd Estructura química

No. CAS : 2758875-01-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

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Revisión del cliente

Descripciòn

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates^[1]. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups^[1]^[2].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

1128.16

Fòrmula

C₆₁H₅₈FN₉O₁₂

No. CAS

2758875-01-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (88.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8864 mL	4.4320 mL	8.8640 mL
5 mM	0.1773 mL	0.8864 mL	1.7728 mL
10 mM	0.0886 mL	0.4432 mL	0.8864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.57%

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Ficha de datos (276 KB) SDS (252 KB)

COA (257 KB) HNMR (477 KB) RP-HPLC (264 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1

[2]. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8864 mL	4.4320 mL	8.8640 mL	22.1600 mL
	5 mM	0.1773 mL	0.8864 mL	1.7728 mL	4.4320 mL
	10 mM	0.0886 mL	0.4432 mL	0.8864 mL	2.2160 mL
	15 mM	0.0591 mL	0.2955 mL	0.5909 mL	1.4773 mL
	20 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1080 mL
	25 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	30 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL
	40 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5540 mL
	50 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL
	60 mM	0.0148 mL	0.0739 mL	0.1477 mL	0.3693 mL
	80 mM	0.0111 mL	0.0554 mL	0.1108 mL	0.2770 mL