PML - PML nuclear body scaffold Gene

Also Known as MYL; RNF71; PP8675; TRIM19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5371

About PML

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,994,716-74,047,827 (from NCBI)

This gene has 22 transcripts (splice variants), 157 orthologues, 80 paralogues and is associated with 76 phenotypes. Ubiquitous expression in fat (RPKM 11.8), spleen (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PML Products (9)

mRNA	Protein	Name
NM_002675.4	NP_002666.1	protein PML isoform 6
NM_033238.3	NP_150241.2	protein PML isoform 1
NM_033239.3	NP_150242.1	protein PML isoform 9
NM_033240.3	NP_150243.2	protein PML isoform 2
NM_033244.4	NP_150247.2	protein PML isoform 5
NM_033246.3	NP_150249.1	protein PML isoform 7
NM_033247.3	NP_150250.2	protein PML isoform 8
NM_033249.3	NP_150252.1	protein PML isoform 10
NM_033250.3	NP_150253.2	protein PML isoform 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SUMO binding	IPI IPI: Inferred from physical interaction	17081985	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	12393906	GOA
enables cobalt ion binding	IDA IDA: Inferred from direct assay	7729428	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	20719947	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9294197	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	7935403	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9230084	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11080164	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12915590	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	7729428	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in PML body organization	IDA IDA: Inferred from direct assay	8643677	GOA
involved in PML body organization	IMP IMP: Inferred from mutant phenotype	17081985	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	9583681	GOA
involved in cellular senescence	IDA IDA: Inferred from direct assay	22002537	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	11259576	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	12402044	GOA
acts upstream of or within maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	17332504	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7935403	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16915281	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	7935403	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12006491	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	9395203	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	19567472	GOA
involved in negative regulation of translation in response to oxidative stress	IDA IDA: Inferred from direct assay	16915281	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15195100	GOA
involved in positive regulation of apoptotic process involved in mammary gland involution	IDA IDA: Inferred from direct assay	11080164	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	16873256	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21803845	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IDA IDA: Inferred from direct assay	22641345	GOA
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22406621	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	12773567	GOA
involved in protein targeting	IDA IDA: Inferred from direct assay	11080164	GOA
involved in protein targeting	IMP IMP: Inferred from mutant phenotype	15195100	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	12915590	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23007646	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	9583681	GOA
involved in regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	21639834	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	9412458	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16915281	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	9412458	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	26119943	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9885291	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11080164	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	16778193	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15195100	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12915590	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9294197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PML Protein Structure

zf-B_box

DUF3583

0
200
400
600
800
882 a.a.

Protein Preferred Names	Protein Names
protein PML	E3 SUMO-protein ligase PML

PML Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PML	P29590	PER2	Homo sapiens	O15055	Anti Bait CoIP	22274616
Intra	PML	P29590	PER2	Homo sapiens	O15055	IF	22274616
Intra	PML	P29590	MAPK7	Homo sapiens	Q13164	Protein Kinase Assay	20832753
Intra	PML	P29590	MAPK7	Homo sapiens	Q13164	Anti Bait CoIP	20832753
Intra	PML	P29590	TBX2	Homo sapiens	Q13207	Anti Bait CoIP	22002537
Intra	PML	P29590	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	29735542
Intra	PML	P29590	PSMA3	Homo sapiens	P25788	Anti Tag CoIP	21988832
Intra	PML	P29590	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PML	P29590	TP53	Homo sapiens	P04637	PLA	25241761
Intra	PML	P29590	TP53	Homo sapiens	P04637	Confocal	21057547
Intra	PML	P29590	TP53	Homo sapiens	P04637	Anti Bait CoIP	12915590
Intra	PML	P29590	MDM2	Homo sapiens	Q00987	Imaging	12915590
Intra	PML	P29590	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	12915590
Intra	PML	P29590	FAS	Homo sapiens	P25445	Anti Bait CoIP	21803845
Intra	PML	P29590	ZBTB16	Homo sapiens	Q05516	Y2H	9294197
Intra	PML	P29590	ZBTB16	Homo sapiens	Q05516	Imaging	9294197
Intra	PML	P29590	TGIF1	Homo sapiens	Q15583	IF	18511908
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Confocal	21840486
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Competition Binding	20389280
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	21840486
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Anti Bait CoIP	21840486
Intra	PML	P29590	DAXX	Homo sapiens	Q9UER7	Anti Bait CoIP	21840486
Intra	PML	P29590	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	17036045
Intra	PML	P29590	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	21057547
Cross	PML	P29590	p03243-1	Human adenovirus C	P03243-1	Anti Bait CoIP	20639899
Cross	PML	P29590	p03243-1	Human adenovirus C	P03243-1	Confocal	20639899
Cross	PML	P29590	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Anti Bait CoIP	16322229
Cross	PML	P29590	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	IF	16322229
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Pull Down	22685230
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Confocal	22685230
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Anti Tag CoIP	22685230

Cross: Cross-species interaction Intra: Intraspecies interaction

PML Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81933	PML Protein Antibody (YA1678)	WB, IHC-P, IHC-F, ICC/IF, IP, FC	Human
HY-P81933A	PML Protein Antibody (YA1678)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P82887	Phospho-PML Protein (Ser518) Antibody (YA2632)	WB, IHC-P	Human
HY-P82887A	Phospho-PML Protein (Ser518) Antibody (YA2632)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Rabies	Lyssa Hydrophobia St Hubert Disease
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Bloom Syndrome	BLM Bs Bls Bloom-Torre-Machacek Syndrome Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1 Mgrisce1 Congenital Telangiectatic Erythema Congenital Telangiectatic Erythema Syndrome Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability Bloom'S Syndrome Bsyn
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Dentatorubral-Pallidoluysian Atrophy	DRPLA Naito-Oyanagi Disease Haw River Syndrome Myoclonic Epilepsy With Choreoathetosis Nod Ataxia, Chorea, Seizures, And Dementia Dentatorubropallidoluysian Atrophy Hrs Naito Oyanagi Disease Dentatorubral Pallidoluysian Atrophy Dentatorubro-Pallidoluysian Atrophy Myoclonic Epilepsies, Progressive Atrophy, Pallidoluysian, Dentatorubral
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N10633	LSTc		99.64%	Unkown
HY-127130	Spicamycin		/	Unkown
HY-175354	PROTAC BET Degrader-13	Degrader	/	Unkown
HY-RS10765	PML Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18592	Pml Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25077	Pml Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PML	MGD	MGI:104662
Macaca mulatta	PML	VGNC	VGNC:99295
Bos taurus	PML	VGNC	VGNC:99292
Felis catus	PML	VGNC	VGNC:99293
Canis familiaris	PML	VGNC	VGNC:99291
Rattus norvegicus	PML	RGD	RGD:1562602
Others	PML	NCBI