DMTr-Ac-5-Fluoro-2'-deoxycytidine-phosphoramidite
DMTr-Ac-5-Fluoro-2'-deoxycytidine-phosphoramidite is the phosphoramidite of 5-Fluoro-2'-deoxycytidine (HY-116217). DMTr-Ac-5-Fluoro-2'-deoxycytidine-phosphoramidite enables the direct automated incorporation of 5-fluoro-2'-deoxycytidine into deoxyoligonucleotides via standard phosphoramidite chemistry, allowing the preparation of deoxyoligonucleotides containing 5-fluoro-2'-deoxycytidine.
For research use only. We do not sell to patients.
- CAS No.: 2392064-11-6
- Formula: C41H49FN5O8P
- Molecular Weight:789.83
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
DMTr-Ac-5-Fluoro-2'-deoxycytidine-phosphoramidite is the phosphoramidite form of 5-Fluoro-2'-deoxycytidine (HY-116217). 5-Fluoro-2'-deoxycytidine is a fluoropyrimidine nucleoside analog and acts as a DNA methyltransferase (DNMT) inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2392064-11-6
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Appearance Solid
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Molecular Weight 789.83
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Formula C41H49FN5O8P
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Color White to off-white
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SMILES
COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)C[C@H](N5C(N=C(C(F)=C5)NC(C)=O)=O)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (126.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2661 mL | 6.3305 mL | 12.6610 mL | 31.6524 mL |
| 5 mM | 0.2532 mL | 1.2661 mL | 2.5322 mL | 6.3305 mL | |
| 10 mM | 0.1266 mL | 0.6330 mL | 1.2661 mL | 3.1652 mL | |
| 15 mM | 0.0844 mL | 0.4220 mL | 0.8441 mL | 2.1102 mL | |
| 20 mM | 0.0633 mL | 0.3165 mL | 0.6330 mL | 1.5826 mL | |
| 25 mM | 0.0506 mL | 0.2532 mL | 0.5064 mL | 1.2661 mL | |
| 30 mM | 0.0422 mL | 0.2110 mL | 0.4220 mL | 1.0551 mL | |
| 40 mM | 0.0317 mL | 0.1583 mL | 0.3165 mL | 0.7913 mL | |
| 50 mM | 0.0253 mL | 0.1266 mL | 0.2532 mL | 0.6330 mL | |
| 60 mM | 0.0211 mL | 0.1055 mL | 0.2110 mL | 0.5275 mL | |
| 80 mM | 0.0158 mL | 0.0791 mL | 0.1583 mL | 0.3957 mL | |
| 100 mM | 0.0127 mL | 0.0633 mL | 0.1266 mL | 0.3165 mL |
DMTr-Ac-5-Fluoro-2'-deoxycytidine-phosphoramidite Related Classifications
HY-207857 Related Classifications
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