2. Autophagy Anti-infection
  3. p62 Bacterial
  4. Dusquetide

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

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Dusquetide

Dusquetide 構造式

CAS 番号 : 931395-42-5

容量 価格（税別） 在庫状況 数量
1 mg $80 在庫あり
5 mg $200 在庫あり
10 mg $320 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Dusquetide 関連抗体

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製品説明

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

体内実験

Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MCF-7 tumor xenografts)[1]
Dosage: 25 mg/kg
Administration: I.v.; days 0, 4, 7, 10, and 14
Result: Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
臨床実験
分子量

553.70

分子式

C25H47N9O5
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence Shortening

RIVPA-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (90.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8060 mL 9.0302 mL 18.0603 mL
5 mM 0.3612 mL 1.8060 mL 3.6121 mL
10 mM 0.1806 mL 0.9030 mL 1.8060 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8060 mL 9.0302 mL 18.0603 mL 45.1508 mL
5 mM 0.3612 mL 1.8060 mL 3.6121 mL 9.0302 mL
10 mM 0.1806 mL 0.9030 mL 1.8060 mL 4.5151 mL
15 mM 0.1204 mL 0.6020 mL 1.2040 mL 3.0101 mL
20 mM 0.0903 mL 0.4515 mL 0.9030 mL 2.2575 mL
25 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8060 mL
30 mM 0.0602 mL 0.3010 mL 0.6020 mL 1.5050 mL
40 mM 0.0452 mL 0.2258 mL 0.4515 mL 1.1288 mL
50 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
60 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7525 mL
80 mM 0.0226 mL 0.1129 mL 0.2258 mL 0.5644 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dusquetide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dusquetide931395-42-5SGX942SGX 942SGX-942p62BacterialSequestosome-1SQSTM1oralmucositisinnatedefenseregulatorimmunesystemheadneckcancerbreastInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-P2076
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