1. Anti-infection
  2. Bacterial
  3. Dusquetide TFA

Dusquetide TFA (Synonyms: SGX942 TFA)

Cat. No.: HY-P2076A
Handling Instructions

Dusquetide (SGX942) TFA is a first-in-class innate defense regulator (IDR). Dusquetide TFA modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide TFA shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

For research use only. We do not sell to patients.

Dusquetide TFA Chemical Structure

Dusquetide TFA Chemical Structure

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Description

Dusquetide (SGX942) TFA is a first-in-class innate defense regulator (IDR). Dusquetide TFA modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide TFA shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

In Vivo

Dusquetide (SGX942) TFA (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1].

Animal Model: Female nude mice (MCF-7 tumor xenografts)[1]
Dosage: 25 mg/kg
Administration: I.v.; days 0, 4, 7, 10, and 14
Result: Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
Molecular Weight

667.72

Formula

C₂₇H₄₈F₃N₉O₇

Sequence

{Arg}{Ile}{Val}{Pro}{Ala}-NH2

Sequence Shortening

RIVPA-NH2

SMILES

C[[email protected]@H](C(N)=O)NC([[email protected]]1N(C([[email protected]](C(C)C)NC([[email protected]]([[email protected]@H](C)CC)NC([[email protected]](CCCNC(N)=N)N)=O)=O)=O)CCC1)=O.OC(C(F)(F)F)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DusquetideSGX942SGX 942SGX-942BacterialoralmucositisinnatedefenseregulatorimmunesystemheadneckcancerbreastInhibitorinhibitorinhibit

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Dusquetide TFA
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HY-P2076A
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