1. Autophagy Anti-infection
  2. p62 Bacterial
  3. Dusquetide

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dusquetide Chemical Structure

Dusquetide Chemical Structure

CAS No. : 931395-42-5

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1 mg USD 80 In-stock
5 mg USD 200 In-stock
10 mg USD 320 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

In Vivo

Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MCF-7 tumor xenografts)[1]
Dosage: 25 mg/kg
Administration: I.v.; days 0, 4, 7, 10, and 14
Result: Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
Clinical Trial
Molecular Weight

553.70

Formula

C25H47N9O5

CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RIVPA-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (90.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8060 mL 9.0302 mL 18.0603 mL
5 mM 0.3612 mL 1.8060 mL 3.6121 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8060 mL 9.0302 mL 18.0603 mL 45.1508 mL
5 mM 0.3612 mL 1.8060 mL 3.6121 mL 9.0302 mL
10 mM 0.1806 mL 0.9030 mL 1.8060 mL 4.5151 mL
15 mM 0.1204 mL 0.6020 mL 1.2040 mL 3.0101 mL
20 mM 0.0903 mL 0.4515 mL 0.9030 mL 2.2575 mL
25 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8060 mL
30 mM 0.0602 mL 0.3010 mL 0.6020 mL 1.5050 mL
40 mM 0.0452 mL 0.2258 mL 0.4515 mL 1.1288 mL
50 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
60 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7525 mL
80 mM 0.0226 mL 0.1129 mL 0.2258 mL 0.5644 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dusquetide
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