1. Anti-infection
  2. Bacterial
  3. Dusquetide

Dusquetide (Synonyms: SGX942)

Cat. No.: HY-P2076
Handling Instructions

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

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Custom Peptide Synthesis

Dusquetide Chemical Structure

Dusquetide Chemical Structure

CAS No. : 931395-42-5

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Description

Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

In Vivo

Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1].

Animal Model: Female nude mice (MCF-7 tumor xenografts)[1]
Dosage: 25 mg/kg
Administration: I.v.; days 0, 4, 7, 10, and 14
Result: Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
Molecular Weight

553.70

Formula

C₂₅H₄₇N₉O₅

CAS No.

931395-42-5

Sequence

{Arg}{Ile}{Val}{Pro}{Ala}-NH2

Sequence Shortening

RIVPA-NH2

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Keywords:

DusquetideSGX942SGX 942SGX-942BacterialoralmucositisinnatedefenseregulatorimmunesystemheadneckcancerbreastInhibitorinhibitorinhibit

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Dusquetide
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