UBL7 - ubiquitin like 7 Gene

Also Known as TCBA1; BMSC-UbP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84993

About UBL7

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,445,977-74,461,188 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 223 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 17.2), brain (RPKM 14.5) and 25 other tissues.

Summary

Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

UBL7 Products (6)

mRNA	Protein	Name
NM_001286739.2	NP_001273668.1	ubiquitin-like protein 7 isoform a
NM_001286740.1	NP_001273669.1	ubiquitin-like protein 7 isoform a
NM_001286741.2	NP_001273670.1	ubiquitin-like protein 7 isoform b
NM_001286742.2	NP_001273671.1	ubiquitin-like protein 7 isoform b
NM_032907.5	NP_116296.1	ubiquitin-like protein 7 isoform a
NM_201265.2	NP_957717.1	ubiquitin-like protein 7 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	36943869	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	36943869	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBL7 Protein Structure

ubiquitin

UBA

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like protein 7	ubiquitin-like 7 (bone marrow stromal cell-derived)

UBL7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBL7	Q96S82	AP1G1	Homo sapiens	O43747-2	Y2H Prey Pooling	25416956
Intra	UBL7	Q96S82	AP1G1	Homo sapiens	O43747-2	Y2H Array	25416956
Intra	UBL7	Q96S82	CAPN7	Homo sapiens	Q7Z479	Y2H Array	25416956
Intra	UBL7	Q96S82	CAPN7	Homo sapiens	Q7Z479	Y2H Prey Pooling	25416956
Intra	UBL7	Q96S82	UBE4B	Homo sapiens	O95155	Anti Tag CoIP	33961781
Intra	UBL7	Q96S82	VBP1	Homo sapiens	P61758	Y2H Array	25416956
Intra	UBL7	Q96S82	ERCC1	Homo sapiens	P07992	Y2H Prey Pooling	25416956
Intra	UBL7	Q96S82	ERCC1	Homo sapiens	P07992	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Phlyctenulosis	Phlyctenular Keratoconjunctivitis Strumous Ophthalmia
Chromosome 15q24 Deletion Syndrome	15q24 Microdeletion Syndrome Del(15)(Q24) Monosomy 15q24 15q24 Microdeletion 15q24 Deletion Interstitial Deletion Of Chromosome 15q24
Arteritic Anterior Ischemic Optic Neuropathy
Severe Nonproliferative Diabetic Retinopathy	High Risk Non Proliferative Diabetic Retinopathy Severe Npdr
Background Diabetic Retinopathy	Non Proliferative Diabetic Retinopathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy
Retinal Microaneurysm	Microaneurysm
Chronic Intestinal Vascular Insufficiency	Chronic Mesenteric Ischemia Cmi - Chronic Mesenteric Ischaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15377	UBL7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBL7	VGNC	VGNC:50128
Felis catus	UBL7	VGNC	VGNC:66776
Rattus norvegicus	UBL7	RGD	RGD:1303055
Mus musculus	UBL7	MGD	MGI:1916709
Macaca mulatta	UBL7	VGNC	VGNC:82267
Canis familiaris	UBL7	VGNC	VGNC:48079
Others	UBL7	NCBI