Ethylenediaminetetra(methylenephosphonic acid) sodium
Ethylenediaminetetramethylenephosphonic acid (EDTMP) sodium is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid sodium is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
For research use only. We do not sell to patients.
- CAS No.: 7651-99-2
- Formula: C6H15N2Na5O12P4
- Molecular Weight:546.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
Ethylenediaminetetramethylenephosphonic acid sodium forms stable complexes with 153Sm and 177Lu, and EDTMP delivers and immobilizes them at bone metastatic lesions. The β or γ rays released during the decay of 153Sm/177Lu produce ionizing radiation locally at the lesions to kill tumor cells, thereby achieving the goal of relieving bone pain[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7651-99-2
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Molecular Weight 546.03
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Formula C6H15N2Na5O12P4
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SMILES
O=P(CN(CP(O)(O[Na])=O)CCN(CP(O)(O[Na])=O)CP(O)(O[Na])=O)(O[Na])O[Na]
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Synonyms
EDTMP sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Askari E, et al. 177Lu-EDTMP for Metastatic Bone Pain Palliation: A Systematic Review and Meta-Analysis. Cancer Biother Radiopharm. 2021;36(5):383-390. [Content Brief]
[2]. Maini CL, et al. 153Sm-EDTMP for bone pain palliation in skeletal metastases. Eur J Nucl Med Mol Imaging. 2004;31 Suppl 1:S171-S178. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethylenediaminetetra(methylenephosphonic acid) sodium Related Classifications
HY-W008951A Related Classifications
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