Ethylenediaminetetra(methylenephosphonic acid)
Based on 1 Customer Validation
Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1429-50-1
- Formula: C6H20N2O12P4
- Molecular Weight:436.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ethylenediaminetetramethylenephosphonic acid forms stable complexes with 153Sm and 177Lu, and EDTMP delivers and immobilizes them at bone metastatic lesions. The β or γ rays released during the decay of 153Sm/177Lu produce ionizing radiation locally at the lesions to kill tumor cells, thereby achieving the goal of relieving bone pain[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1429-50-1
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Appearance Solid
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Molecular Weight 436.12
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Formula C6H20N2O12P4
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Color White to off-white
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SMILES
O=P(O)(CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O)O
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Synonyms
EDTMP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 3.7 mg/mL (8.48 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (779 KB)
- English - EN (779 KB)
- Français - FR (779 KB)
- Deutsch - DE (779 KB)
- Norwegian - NO (779 KB)
- Español - ES (779 KB)
- Swedish - SV (779 KB)
- Italian - IT (779 KB)
- Korean - KR (779 KB)
- Portuguese - PT (779 KB)
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Handling Instructions (2659 KB)
References
[1]. Askari E, et al. 177Lu-EDTMP for Metastatic Bone Pain Palliation: A Systematic Review and Meta-Analysis. Cancer Biother Radiopharm. 2021;36(5):383-390. [Content Brief]
[2]. Maini CL, et al. 153Sm-EDTMP for bone pain palliation in skeletal metastases. Eur J Nucl Med Mol Imaging. 2004;31 Suppl 1:S171-S178. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2929 mL | 11.4647 mL | 22.9295 mL | 57.3237 mL |
| 5 mM | 0.4586 mL | 2.2929 mL | 4.5859 mL | 11.4647 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ethylenediaminetetra(methylenephosphonic acid) Related Classifications
HY-W008951 Related Classifications
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