Ethylenediaminetetra(methylenephosphonic acid)  (Synonyms: EDTMP)

Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with ¹⁵³Sm and ¹⁷⁷Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers^[1][2][3].

Ethylenediaminetetramethylenephosphonic acid forms stable complexes with ¹⁵³Sm and ¹⁷⁷Lu, and EDTMP delivers and immobilizes them at bone metastatic lesions. The β or γ rays released during the decay of ¹⁵³Sm/¹⁷⁷Lu produce ionizing radiation locally at the lesions to kill tumor cells, thereby achieving the goal of relieving bone pain^[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

436.12

C₆H₂₀N₂O₁₂P₄

1429-50-1

Solid

White to off-white

O=P(O)(CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O)O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Askari E, et al. ¹⁷⁷Lu-EDTMP for Metastatic Bone Pain Palliation: A Systematic Review and Meta-Analysis. Cancer Biother Radiopharm. 2021;36(5):383-390.

  [2]. Maini CL, et al. 153Sm-EDTMP for bone pain palliation in skeletal metastases. Eur J Nucl Med Mol Imaging. 2004;31 Suppl 1:S171-S178.

  [3]. Holmes RA. [153Sm] EDTMP: a potential therapy for bone cancer pain. InSeminars in nuclear medicine 1992 Jan 1 (Vol. 22, No. 1, pp. 41-45). WB Saunders.