Fibrinogen-Binding Peptide TFA
Based on 1 publication(s) in Google Scholar
Fibrinogen-Binding Peptide TFA is a Fibrinogen-binding peptide. Fibrinogen-Binding Peptide TFA inhibits platelet adhesion to vitronectin and fibrinogen. Fibrinogen-Binding Peptide TFA inhibits platelet aggregation in ADP-stimulated platelet-rich plasma and in thrombin-stimulated washed platelets. Fibrinogen-Binding Peptide TFA can be used for research on thrombosis.
For research use only. We do not sell to patients.
- Purity : 99.32%
- Formula: C27H40F3N7O10
- Molecular Weight:679.64
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fibrinogen-Binding Peptide TFA
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Biological Activity
Description
In Vitro
Fibrinogen-Binding Peptide (1.2 mM; 90 min) TFA specifically inhibits the adhesion of activated platelets to vitronectin at a concentration of 1.2 mM, with an inhibition rate of 54%[1].
Fibrinogen-Binding Peptide (1 mM) TFA specifically inhibits the adhesion of activated platelets to fibrinogen by 58% at 1 mM[1].
Fibrinogen-Binding Peptide TFA inhibits platelet aggregation in PRP, and its potency depends on its specific amino acid sequence[1].
Fibrinogen-Binding Peptide TFA inhibits the adhesion of activated platelets to fibrinogen[2].
Fibrinogen-Binding Peptide TFA inhibits thrombin-induced platelet aggregation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 679.64
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Formula C27H40F3N7O10
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Stem Cell Res Ther
Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration. [Abstract]2020 Feb 21;11(1):76. PMID: 32085799
Solvent & Solubility
In Vitro:
H2O : 250 mg/mL (367.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Gartner TK, et al. The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1991 Oct;198(1):649-55. [Content Brief]
[2]. Gartner TK, et al. The peptides APLHK, EHIPA and GAPL are hydropathically equivalent peptide mimics of a fibrinogen binding domain of glycoprotein IIb/IIIa. Biochemical and biophysical research communications. 1991 Nov 14;180(3):1446-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4714 mL | 7.3568 mL | 14.7137 mL | 36.7842 mL |
| 5 mM | 0.2943 mL | 1.4714 mL | 2.9427 mL | 7.3568 mL | |
| 10 mM | 0.1471 mL | 0.7357 mL | 1.4714 mL | 3.6784 mL | |
| 15 mM | 0.0981 mL | 0.4905 mL | 0.9809 mL | 2.4523 mL | |
| 20 mM | 0.0736 mL | 0.3678 mL | 0.7357 mL | 1.8392 mL | |
| 25 mM | 0.0589 mL | 0.2943 mL | 0.5885 mL | 1.4714 mL | |
| 30 mM | 0.0490 mL | 0.2452 mL | 0.4905 mL | 1.2261 mL | |
| 40 mM | 0.0368 mL | 0.1839 mL | 0.3678 mL | 0.9196 mL | |
| 50 mM | 0.0294 mL | 0.1471 mL | 0.2943 mL | 0.7357 mL | |
| 60 mM | 0.0245 mL | 0.1226 mL | 0.2452 mL | 0.6131 mL | |
| 80 mM | 0.0184 mL | 0.0920 mL | 0.1839 mL | 0.4598 mL | |
| 100 mM | 0.0147 mL | 0.0736 mL | 0.1471 mL | 0.3678 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fibrinogen-Binding Peptide TFA Related Classifications
HY-P1741A Related Classifications
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