MUC7 - mucin 7, secreted Gene

Also Known as MG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4589

About MUC7

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,430,492-70,482,997 (from NCBI)

This gene has 7 transcripts (splice variants), 25 orthologues and is associated with 1 phenotype. Restricted expression toward salivary gland (RPKM 5748.3).

Summary

This gene encodes a small salivary Mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 Amino acids. This antimicrobial protein has Antibacterial and Antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

MUC7 Products (3)

mRNA Protein Name
NM_001145006.2 NP_001138478.1 mucin-7 precursor
NM_001145007.2 NP_001138479.1 mucin-7 precursor
NM_152291.3 NP_689504.2 mucin-7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16203048 GOA
Biological Process GO Annotation Evidence Références Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12543672 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12543672 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-7

  • MUC-7

MUC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MUC7 Q8TAX7 AMY1A Homo sapiens P0DTE7
Far-WB
16203048
Intra
MUC7 Q8TAX7 AMY1A Homo sapiens P0DTE7
Y2H
16203048
Intra
MUC7 Q8TAX7 STATH Homo sapiens P02808
Y2H
16203048
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Chronic Ethmoiditis

  • Chronic Ethmoidal Sinusitis

  • Chronic Ethmoid Sinusitis

  • Ethmoidal Sinusitis - Chronic
Burning Mouth Syndrome

  • Orodynia

  • Stomatodynia

  • Stomatopyrosis

  • Bms

  • Burning Mouth Disorder

  • Oral Dysesthesia

  • Sore Mouth Syndrome

  • Bms - [Burning Mouth Syndrome]
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Sialolithiasis

  • Sialolith

  • Stone Of Salivary Gland Or Duct

  • Salivary Gland Calculi

  • Salivary Gland Stone

  • Calculus Of Salivary Gland Or Duct

  • Calculus Of Salivary Gland

  • Salivary Calculus

  • Salivary Gland Calculus

  • Salivary Stone

  • Salivary Duct Calculi

  • Sialodocholithiasis
Bile Duct Cystadenocarcinoma

  • Biliary Cystadenocarcinoma

  • Intrahepatic Bile Duct Cystadenocarcinoma

  • Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma
Enamel Erosion
Ethmoid Sinusitis

  • Ethmoidal Sinusitis

  • Ethmoiditis
Tooth Erosion

  • Generalized Erosion

  • Localized Erosion

  • Generalized Erosions

  • Erosion, Localized
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08847 MUC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown