DDIT4 - DNA damage inducible transcript 4 Gene

Also Known as Dig2; REDD1; REDD-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54541

About DDIT4

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,273,924-72,276,036 (from NCBI)

This gene has 5 transcripts (splice variants), 257 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 89.7), fat (RPKM 84.2) and 25 other tissues.

Summary

Predicted to enable 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DDIT4 Products (1)

mRNA Protein Name
NM_019058.4 NP_061931.1 DNA damage-inducible transcript 4 protein

DDIT4 Protein Structure

RTP801_C

RTP801_C: RTP801 C-terminal region (104 - 223)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

DNA damage-inducible transcript 4 protein

  • HIF-1 responsive protein RTP801

DDIT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Atrophy
  • Atrophic Condition Of Skin

  • Atrophoderma

  • Atrophy - Skin

Hyperinsulinemic Hypoglycemia, Familial, 1
  • HHF1

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Familial Hyperinsulinemic Hypoglycemia 1

  • Congenital Hyperinsulinism

  • Phhi

  • Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

  • Hypoglycemia, Hyperinsulinemic, Of Infancy

  • Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

  • Nesidioblastosis Of Pancreas

  • Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

  • Hyperinsulinism, Congenital

  • Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

  • Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

  • Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

  • Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

  • Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus DDIT4 VGNC VGNC:61390
Canis familiaris DDIT4 VGNC VGNC:39837
Mus musculus DDIT4 MGD MGI:1921997
Bos taurus DDIT4 VGNC VGNC:27948
Rattus norvegicus DDIT4 RGD RGD:621731
Others DDIT4 NCBI