Mumefural
Based on 1 Customer Validation
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment.
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- Pureza: 95.17%
- No. CAS: 222973-44-6
- Fòrmula: C12H12O9
- Peso molecular:300.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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NF-κB |
TLR4 |
P-selectin |
E-selectin |
TNF-α |
Mumefural (20-80 mg/kg; oral; daily for 42 days) ameliorates cognitive impairment in chronic cerebral hypoperfusion via regulating the septohippocampal cholinergic system and neuroinflammation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats, FeCl3-induced arterial thrombosis model[1]
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Dosage:0.1, 1, or 10 mg/kg
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Administration:Intraperitoneal injection, 30 min before 35% FeCl3 treatment
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Result:Significantly improved blood flow by inhibiting occlusion and thrombus formation. Prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels.
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Animal Model:Male Wistar rats, Chronic cerebral hypoperfusion (CCH) model[2]
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Dosage:20, 40, or 80 mg/kg
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Administration:Oral, once a day for 42 days
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Result:Significantly improved cognitive impairment. Inhibited cholinergic system dysfunction, attenuated choline acetyltransferase-positive cholinergic neuron loss. Inhibited myelin basic protein degradation and increased the hippocampal expression of synaptic markers and cognition-related proteins. Reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4/MyD88, NLRP3, and NF-κB.
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Animal Model:SD rats[1]
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Dosage:2 or 10 mg/kg
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Administration:IV or PO (Pharmacokinetic Analysis)
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Result:Plasma pharmacokinetic parameters of Mumefural in SD rats[1]
T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng⋅h/mL) F (%) IV (2 mg/kg) 0.14±0.05 0.08±0 1894.54±580.66 564.73±178.35 - PO (2 mg/kg) 0.69±0.69 0.31±0.13 1731.61±290.64 1043.28±202.37 36.95±7.17
AUC(0–t): area under the curve from the time of dosing to infinity; Cmax: maximum concentration; F: bioavailability; T1/2: terminal half-life; Tmax: time of the maximum concentration; SD: standard deviation; F was calculated using the following formula
Chemical Information
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No. CAS 222973-44-6
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Appearance Solid
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Peso molecular 300.22
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Fòrmula C12H12O9
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Color White to off-white
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SMILES
O=C(CC(C(O)=O)(O)CC(O)=O)OCC1=CC=C(C=O)O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (333.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bang J, et al. Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis. Nutrients. 2020 Dec 10;12(12):3795. [Content Brief]
[2]. Bang J, et al. Mumefural Ameliorates Cognitive Impairment in Chronic Cerebral Hypoperfusion via Regulating the Septohippocampal Cholinergic System and Neuroinflammation. Nutrients. 2019 Nov 13;11(11):2755. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3309 mL | 16.6545 mL | 33.3089 mL | 83.2723 mL |
| 5 mM | 0.6662 mL | 3.3309 mL | 6.6618 mL | 16.6545 mL | |
| 10 mM | 0.3331 mL | 1.6654 mL | 3.3309 mL | 8.3272 mL | |
| 15 mM | 0.2221 mL | 1.1103 mL | 2.2206 mL | 5.5515 mL | |
| 20 mM | 0.1665 mL | 0.8327 mL | 1.6654 mL | 4.1636 mL | |
| 25 mM | 0.1332 mL | 0.6662 mL | 1.3324 mL | 3.3309 mL | |
| 30 mM | 0.1110 mL | 0.5551 mL | 1.1103 mL | 2.7757 mL | |
| 40 mM | 0.0833 mL | 0.4164 mL | 0.8327 mL | 2.0818 mL | |
| 50 mM | 0.0666 mL | 0.3331 mL | 0.6662 mL | 1.6654 mL | |
| 60 mM | 0.0555 mL | 0.2776 mL | 0.5551 mL | 1.3879 mL | |
| 80 mM | 0.0416 mL | 0.2082 mL | 0.4164 mL | 1.0409 mL | |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.3331 mL | 0.8327 mL |
Mumefural Related Classifications
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