NLRP3-IN-81
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2922814-85-3
- Fòrmula: C16H15F3N2O3S
- Peso molecular:372.36
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Caspase
More
Actividad biológica
|
Caspase-1 |
IL-1β |
NLRP3 inflammasome 0.029 μM (EC50) |
| Species | Dose | Route | AUC0-t | MRT0-t | Tmax | T1/2 | Cmax | CL |
|---|---|---|---|---|---|---|---|---|
| Mice | 1 mg/kg | i.v. | 32710 ng/L.h | 0.07 h | 0.03 h | 0.06 h | 299.4 μg/L | 31.89 L/h/kg |
| Mice | 10 mg/kg | i.p. | 65180 ng/L.h | 23.15 h | 0.08 h | 0.33 h | 173.83 μg/L | 152.46 L/h/kg |
Chemical Information
-
No. CAS 2922814-85-3
-
Peso molecular 372.36
-
Fòrmula C16H15F3N2O3S
-
SMILES
O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-81 Related Classifications
HY-174312 Related Classifications
Powered by Bioz