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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
52 Results for "
proteoglycans
" in MedChemExpress (MCE) Product Catalog:
Products (52)
52 Results for "proteoglycans" in MCE Product Catalog:
Target:
Áreas de investigación:
UDP-glucose dehydrogenase is a cytosolic enzyme that catalyzes the oxidation of UDP-glucose to UDP-glucuronate. UDP-glucose dehydrogenase plays a critical role in synthesis of glycosaminoglycans and proteoglycans .
Referencia número: HY-P4794A
Target:
Áreas de investigación:
Referencia número: HY-P0063A
No. CAS: 300801-03-0
Synonyms: GHK-Cu acetate
Target:
Áreas de investigación:
Copper tripeptide (GHK-Cu) acetate is a tripeptide. During wound healing, Copper tripeptide acetate may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide acetate has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide acetate is a natural modulator of multiple cllular pathways in skin regeneration .
Áreas de investigación:
Ki11502 is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGF β/α receptors with IC50 values less than 10 nM. Ki11502 selectively inhibits PDGF β receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis) and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib (HY-15463) resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis .
Referencia número: HY-114581
No. CAS: 106314-87-8
Target:
Áreas de investigación:
U27391 is a metalloproteinase inhibitor. U27391 inhibits rhIL-1β Induced proteoglycan loss .
Referencia número: HY-P4794
No. CAS: 193613-75-1
Target:
Áreas de investigación:
Referencia número: HY-172482A
DSPE-PEG3400-TAASGVRSMH is a PEG compound which composed of DSPE and TAASGVRSMH. TAASGVRSMH has a strong affinity for the NG2 proteoglycan on the PC membrane. DSPE-PEG3400-TAASGVRSMH can be used for drug delivery .
Referencia número: HY-174529
Target:
Áreas de investigación:
Human TGFBR3 mRNA encodes the human transforming growth factor beta receptor 3 (TGFBR3) protein, a transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers.
Referencia número: HY-110135R
No. CAS: 374620-70-9
Target:
Áreas de investigación:
NBI-31772 (Standard) is the analytical standard of NBI-31772. This product is intended for research and analytical applications. NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation .
Referencia número: HY-187685
No. CAS: 147485-09-4
Target:
Áreas de investigación:
L 696418 is a MMP-3 inhibitor with a Ki value of 310 nM. L 696418 inhibits MMP-3 activity, thereby preventing the release of proteoglycans from cartilage. L 696418 reduces proteoglycan release in rabbit knee joints exposed to interleukin-1β (IL-1β). L 696418 can be used in research related to cartilage degradation .
Referencia número: HY-187239A
Target:
Áreas de investigación:
DSG-PEG2000-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: distearoylglycerol (DSG) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DSG-PEG2000-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
Referencia número: HY-187317
Target:
Áreas de investigación:
DOPE-PEG1000-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DOPE-PEG1000-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
Referencia número: HY-187317A
Target:
Áreas de investigación:
DOPE-PEG2000-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DOPE-PEG2000-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
Referencia número: HY-187317B
Target:
Áreas de investigación:
DOPE-PEG3400-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DOPE-PEG3400-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
Referencia número: HY-187317C
Target:
Áreas de investigación:
DOPE-PEG5000-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DOPE-PEG5000-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
Referencia número: HY-187327
Target:
Áreas de investigación:
DMG-PEG1000-TAT is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, PEG, and TAT peptide (YGRKKRRQRRR) (HY-P0281) as the terminal targeting/functional ligand. DMG-PEG1000-TAT can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against non-specific cell membrane penetration (heparan sulfate proteoglycans).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
