(Z)-Aconitic acid
Based on 2 publication(s) in Google Scholar
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.28%
- No. CAS: 585-84-2
- Fòrmula: C6H6O6
- Peso molecular:174.11
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (Z)-Aconitic acid
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Actividad biológica
(Z)-Aconitic acid (10-90 μM; 2 h) reduces TNF-α release and IκB-α phosphorylation in LPS-stimulated THP-1 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6j male mice (8-10 weeks old) + antigen-induced arthritis (AIA) model or monosodium urate-induced gout model[1]
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Dosage:10 mg/kg, 30 mg/kg, 90 mg/kg (0.5% w/v CMC suspension); 30 mg/kg (for gout model)
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Administration:Oral gavage, once, 24 h after antigen challenge in AIA model; Oral gavage, once, 15 h after MSU injection in gout model
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Result:Reduced total leukocytes and neutrophils in the synovial cavity and periarticular tissue, MPO activity, CXCL-1 levels in periarticular tissues, arthritis index, and hypernociception (AIA).
Significantly reduced total leukocyte and neutrophil accumulation into the synovial cavity at 30 mg/kg (gout model).
Chemical Information
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No. CAS 585-84-2
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Appearance Solid
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Peso molecular 174.11
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Fòrmula C6H6O6
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Color White to light yellow
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SMILES
O=C(O)/C([H])=C(C(O)=O)/CC(O)=O.
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Synonyms
cis-Aconitic acid
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Agric Food Chem
Pathway-Based Metabolomics Analysis Reveals Biosynthesis of Key Flavor Compounds in Mango. [Abstract]2022 Aug 31;70(34):10389-10399. PMID: 34792344 -
Life Sci
Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]2024 Jun 15:347:122682. PMID: 38702025
Solvente y solubilidad
H2O : 100 mg/mL (574.35 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (574.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (574.35 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.7435 mL | 28.7175 mL | 57.4350 mL | 143.5874 mL |
| 5 mM | 1.1487 mL | 5.7435 mL | 11.4870 mL | 28.7175 mL | |
| 10 mM | 0.5743 mL | 2.8717 mL | 5.7435 mL | 14.3587 mL | |
| 15 mM | 0.3829 mL | 1.9145 mL | 3.8290 mL | 9.5725 mL | |
| 20 mM | 0.2872 mL | 1.4359 mL | 2.8717 mL | 7.1794 mL | |
| 25 mM | 0.2297 mL | 1.1487 mL | 2.2974 mL | 5.7435 mL | |
| 30 mM | 0.1914 mL | 0.9572 mL | 1.9145 mL | 4.7862 mL | |
| 40 mM | 0.1436 mL | 0.7179 mL | 1.4359 mL | 3.5897 mL | |
| 50 mM | 0.1149 mL | 0.5743 mL | 1.1487 mL | 2.8717 mL | |
| 60 mM | 0.0957 mL | 0.4786 mL | 0.9572 mL | 2.3931 mL | |
| 80 mM | 0.0718 mL | 0.3590 mL | 0.7179 mL | 1.7948 mL | |
| 100 mM | 0.0574 mL | 0.2872 mL | 0.5743 mL | 1.4359 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(Z)-Aconitic acid Related Classifications
HY-W016814 Related Classifications
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