1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. PPAR
    Cytochrome P450
    Drug Metabolite
  3. Gemfibrozil 1-O-β-glucuronide

Gemfibrozil 1-O-β-glucuronide 

Cat. No.: HY-129993
Handling Instructions

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.

For research use only. We do not sell to patients.

Gemfibrozil 1-O-β-glucuronide Chemical Structure

Gemfibrozil 1-O-β-glucuronide Chemical Structure

CAS No. : 91683-38-4

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Description

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].

IC50 & Target[1]

CYP2C8

4.07 μM (IC50)

In Vitro

Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC50 of 24.3 μM[1].
Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC50s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation[1].
Gemfibrozil 1-O-β-Glucuronide has an IC50 of 243 μM for the CYP3A4- mediated metabolism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.46

Formula

C₂₁H₃₀O₉

CAS No.

91683-38-4

SMILES

O[[email protected]]1[[email protected]](OC(C(C)(C)CCCOC2=CC(C)=CC=C2C)=O)O[[email protected]](C(O)=O)[[email protected]@H](O)[[email protected]@H]1O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gemfibrozil 1-O-β-glucuronidePPARCytochrome P450Drug MetabolitePeroxisome proliferator-activated receptorsCYPsmetaboliteGemfibrozilCI-719P450CYPOATP2OATP1B1CerivastatinM1M23CYP3A4Inhibitorinhibitorinhibit

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Product Name:
Gemfibrozil 1-O-β-glucuronide
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HY-129993
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