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ACTR3 - actin related protein 3 Gene

Also Known as ARP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10096

About ACTR3

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,889,934-113,962,596 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 65.6), appendix (RPKM 59.7) and 24 other tissues.

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

ACTR3 Products (2)

mRNA	Protein	Name
NM_001277140.1	NP_001264069.1	actin-related protein 3 isoform 2
NM_005721.5	NP_005712.1	actin-related protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	29058690	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17220302	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17220302	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	9230079	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16767080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR3 Protein Structure

Actin

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
actin-related protein 3	ARP3 actin related protein 3 homolog

ACTR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Y2H Array	32814053
Intra	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Y2H Pooling	32814053
Intra	ACTR3	P61158	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32814053
Intra	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Y2H Pooling	32814053
Intra	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Validated Y2H	32814053
Intra	ACTR3	P61158	CDK5	Homo sapiens	Q00535	Y2H Array	32814053
Intra	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Pooling	32814053
Intra	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Validated Y2H	32814053
Intra	ACTR3	P61158	BRPF3	Homo sapiens	Q9ULD4-2	Y2H Array	32814053
Intra	ACTR3	P61158	UNG	Homo sapiens	P13051-2	Y2H Pooling	32814053
Intra	ACTR3	P61158	UNG	Homo sapiens	P13051-2	Validated Y2H	32814053
Intra	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Validated Y2H	32814053
Intra	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Y2H Pooling	32814053
Intra	ACTR3	P61158	APH1A	Homo sapiens	Q96BI3-2	Y2H Array	32814053
Intra	ACTR3	P61158	JUND	Homo sapiens	P17535	TAP	20195357
Intra	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Y2H Array	32814053
Intra	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Y2H Pooling	32814053
Intra	ACTR3	P61158	HSPD1	Homo sapiens	P10809	Validated Y2H	32814053
Intra	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32814053
Intra	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Y2H Array	32814053
Intra	ACTR3	P61158	STUB1	Homo sapiens	Q9UNE7	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACTR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76733	ARP3/ACTR3 Protein, Human (sf9, His-GST)	P61158 (A2-S418)	≥ 90%, as determined by reducing SDS-PAGE.

ACTR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82010	Actin Related Protein 3 Antibody (YA1755)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84421	Actin Related Protein 3 Antibody (YA4118)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84421A	Actin Related Protein 3 Antibody (YA4118)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84422	Actin Related Protein 3 Antibody (YA4119)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
HY-P84422A	Actin Related Protein 3 Antibody (YA4119)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
HY-P85840	Actin Related Protein 3 Antibody (YA5532)	WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Colorectal Cancer, Hereditary Nonpolyposis, Type 2	HNPCC2 Fcc2 Coca2 Hereditary Nonpolyposis Colorectal Cancer Type 2 Colon Cancer, Familial Nonpolyposis, Type 2 Familial Nonpolyposis Colon Cancer Type 2 Hereditary Non-Polyposis Colorectal Cancer 2 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00231	ACTR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00232	ACTR3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19403	Actr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25895	Actr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACTR3	VGNC	VGNC:50033
Felis catus	ACTR3	VGNC	VGNC:59557
Macaca mulatta	ACTR3	VGNC	VGNC:69436
Canis familiaris	ACTR3	VGNC	VGNC:59392
Rattus norvegicus	ACTR3	RGD	RGD:71024
Mus musculus	ACTR3	MGD	MGI:1921367
Others	ACTR3	NCBI