CNMD - chondromodulin Gene

Also Known as CHM1; CHM-I; LECT1; BRICD3; MYETS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11061

About CNMD

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,703,264-52,739,820 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 1 paralogue. Biased expression in thyroid (RPKM 1.5), salivary gland (RPKM 1.3) and 3 other tissues.

Summary

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with Other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CNMD Products (2)

mRNA Protein Name
NM_001011705.2 NP_001011705.1 leukocyte cell-derived chemotaxin 1 isoform 2 precursor
NM_007015.3 NP_008946.1 leukocyte cell-derived chemotaxin 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
16980969 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNMD Protein Structure

BRICHOS

BRICHOS: BRICHOS domain (105 - 201)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

leukocyte cell-derived chemotaxin 1

  • BRICHOS domain containing 3

Recombinant CNMD Proteins

Cat. No. Product Name Accession Purity
HY-P75906 LECT1 Protein, Human (HEK293, Fc) NP_001011705.1 (E215-V333) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Infective Endocarditis

  • Bacterial Endocarditis

  • Endocarditis, Infective

  • Infectious Endocarditis

  • Endocarditis Infective
Chondrosarcoma

  • Cartilaginous Cancer

  • Chondrosarcoma Of Bone

  • Primary Chondrosarcoma Of The Bone

  • CHDSA
Heart Valve Disease

  • Heart Valve Diseases

  • Valvular Heart Disease

  • Valvular Heart Diseases

  • Heart Valve Prolapse
Aortic Valve Disease 2

  • Aortic Valve Stenosis

  • Aortic Stenosis

  • Rheumatic Aortic Stenosis

  • AOVD2

  • Bicuspid Aortic Valve

  • Rheumatic Aortic Valve Stenosis

  • Valvular Aortic Stenosis

  • Aortic Valve Disease, Type 2

  • Aortic Valve Stricture

  • Aortic Valve Obstruction

  • Obstructed Aorta Valve

  • Rheumatic Aortic Obstruction

  • Rheumatic Aortic Valve Obstruction

  • Rheumatic Aortic Stricture

  • Aortic Valve Regurgitation

  • Aortic Insufficiency With Stenosis

  • Rheumatic Aortic Valve Stenosis With Insufficiency

  • Rheumatic Aortic Stenosis With Incompetence

  • Rheumatic Aortic Stenosis With Regurgitation
Hydrolethalus Syndrome 2

  • HLS2

  • Hydrolethalus Syndrome, Type 2
Pleomorphic Adenoma

  • Mixed Tumor Of The Salivary Gland

  • Adenoma Pleomorphic

  • Adenoma, Pleomorphic

  • Mixed Salivary Gland Tumor

  • Mixed Tumor, Not Otherwise Specified
Cerebral Amyloid Angiopathy, Itm2b-Related, 1

  • Dementia, Familial British

  • Fbd

  • Presenile Dementia With Spastic Ataxia

  • Familial British Dementia

  • Abri Amyloidosis

  • Cerebral Amyloid Angiopathy, British Type

  • Itm2b-Related Cerebral Amyloid Angiopathy 1

  • Familial Dementia, British Type

  • Cerebral Amyloid Angiopathy, Itm2b-Related 1

  • CAA-ITM2B1

  • Cerebral Amyloid Angiopathy British Type

  • Dementia, Familial, British
Gestational Trophoblastic Neoplasm

  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos
Trophoblastic Neoplasm

  • Trophoblastic Tumor

  • Trophoblastic Neoplasms
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02891 CNMD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20707 Cnmd Mouse Pre-designed siRNA Set A / Unkown
HY-RS27218 Cnmd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNMD VGNC VGNC:27507
Canis familiaris CNMD VGNC VGNC:54287
Rattus norvegicus CNMD RGD RGD:620176
Macaca mulatta CNMD VGNC VGNC:71191
Mus musculus CNMD MGD MGI:1341171
Felis catus CNMD VGNC VGNC:61020
Others CNMD NCBI