Scn4a - sodium channel, voltage-gated, type IV, alpha Gene

Also Known as mH2; SkM1; Nav1.4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110880

About Scn4a

Chromosome 11: 106,209,418-106,244,114 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 191 orthologues, 26 paralogues and is associated with 39 phenotypes. Biased expression in mammary gland adult (RPKM 6.9), heart adult (RPKM 4.1) and 3 other tissues.

Summary

Enables voltage-gated Sodium Channel activity. Acts upstream of or within sodium ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in axon. Is expressed in heart; heart ventricle; and testis. Used to study hyperkalemic periodic paralysis and hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4). [provided by Alliance of Genome Resources, Apr 2022]

Scn4a Products (2)

mRNA Protein Name
NM_133199.3 NP_573462.2 sodium channel protein type 4 subunit alpha
NM_001403641.1 NP_001390570.1 sodium channel protein type 4 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
11834499 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
11834499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn4a Protein Structure

Ion_trans

Ion_trans: pfam00520 (129 - 450)

Ion_trans

Ion_trans: pfam00520 (570 - 783)

Na_trans_assoc

Na_trans_assoc: pfam06512 (809 - 1019)

Ion_trans

Ion_trans: pfam00520 (1023 - 1297)

Na_channel_gate

Na_channel_gate: cd13433 (1289 - 1341)

Ion_trans

Ion_trans: pfam00520 (1346 - 1602)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1841 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 4 subunit alpha

  • sodium channel alpha-subunit

  • sodium channel protein skeletal muscle subunit alpha

  • sodium channel protein type IV subunit alpha

  • sodium channel, voltage-gated, type IV, alpha polypeptide

  • voltage-gated sodium channel subunit alpha Nav1.4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12537 SCN4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12538 Scn4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12539 Scn4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn4a NCBI NCBI:6329