2. Gene
  3. ADAMTS7 - ADAM metallopeptidase with thrombospondin type 1 motif 7 Gene

ADAMTS7 - ADAM metallopeptidase with thrombospondin type 1 motif 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADAM-TS7; ADAMTS-7; ADAM-TS 7

Gene ID: 11173 | Gene type: protein coding

About ADAMTS7

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,759,206-78,811,464 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 25 paralogues. Broad expression in endometrium (RPKM 4.6), heart (RPKM 3.1) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

ADAMTS7 Products(1)

mRNA Protein Name
NM_014272.5 NP_055087.2 A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein

ADAMTS7 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (44 - 184)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (242 - 452)

TSP_1

TSP_1: Thrombospondin type 1 domain (542 - 592)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (699 - 809)

TSP_1

TSP_1: Thrombospondin type 1 domain (828 - 879)

TSP_1

TSP_1: Thrombospondin type 1 domain (949 - 994)

TSP_1

TSP_1: Thrombospondin type 1 domain (1418 - 1463)

TSP_1

TSP_1: Thrombospondin type 1 domain (1469 - 1497)

TSP_1

TSP_1: Thrombospondin type 1 domain (1526 - 1570)

TSP_1

TSP_1: Thrombospondin type 1 domain (1576 - 1625)

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  • 1686 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 7

COMPase

Related Diseases

Diseases Alias
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Weill-Marchesani Syndrome

Gemss Syndrome

Spherophakia-Brachymorphia Syndrome

Marchesani-Weill Syndrome

Wms

Congenital Mesodermal Dystrophy

Mesodermal Dysmorphodystrophy, Congenital

Spherophakia Brachymorphia Syndrome

Mesodermal Dysmorphodystrophy Congenital

Wm Syndrome

Brachydactyly-Spherophakia Syndrome

Brachymorphy With Spherophakia Syndrome

Congenital Mesodermal Dysmorphodystrophy

Marchesani Syndrome

Weill-Marchesani Syndrome, Autosomal Recessive

Weill-Marchesani Syndrome, Autosomal Dominant
Multiple Epiphyseal Dysplasia

Med

Polyepiphyseal Dysplasia

Edm

Epiphyseal Dysplasia, Multiple, 1

Epiphyseal Dysplasia, Multiple, 2

Epiphyseal Dysplasia, Multiple, 3

Epiphyseal Dysplasia, Multiple, 4

Epiphyseal Dysplasia, Multiple, 5

Epiphyseal Dysplasia, Multiple

Edm1

Edm2

Edm3

Edm4

Edm5

Epiphyseal Dysplasia, Fairbank Type

Epiphyseal Dysplasia, Ribbing Type

Multiple Epiphyseal Dysplasia, Autosomal Dominant

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Rmed

Dysplasia, Epiphyseal, Multiple

Osteochondrodysplasias
Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd
Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162284 BAY-9835 Antagonist / Unkown
HY-RS00307 ADAMTS7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADAMTS7 MGD MGI:1347346
Macaca mulatta ADAMTS7 VGNC VGNC:82098
Canis familiaris ADAMTS7 VGNC VGNC:37603
Rattus norvegicus ADAMTS7 RGD RGD:1306713
Bos taurus ADAMTS7 VGNC VGNC:57155
Felis catus ADAMTS7 VGNC VGNC:82366
Others ADAMTS7 NCBI