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ADAMTS7 - ADAM metallopeptidase with thrombospondin type 1 motif 7 Gene

Also Known as ADAM-TS7; ADAMTS-7; ADAM-TS 7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11173

About ADAMTS7

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,759,206-78,811,464 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 25 paralogues. Broad expression in endometrium (RPKM 4.6), heart (RPKM 3.1) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

ADAMTS7 Products (1)

mRNA	Protein	Name
NM_014272.5	NP_055087.2	A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	18485748	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18485748	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	22247065	GOA
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	18485748	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	18485748	GOA
involved in negative regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	22247065	GOA
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	18485748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS7 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
300
600
900
1200
1500
1686 a.a.

Protein Preferred Names	Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 7	COMPase

Related Diseases

Diseases	Alias
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Multiple Epiphyseal Dysplasia	Med Polyepiphyseal Dysplasia Edm Epiphyseal Dysplasia, Multiple, 1 Epiphyseal Dysplasia, Multiple, 2 Epiphyseal Dysplasia, Multiple, 3 Epiphyseal Dysplasia, Multiple, 4 Epiphyseal Dysplasia, Multiple, 5 Epiphyseal Dysplasia, Multiple Edm1 Edm2 Edm3 Edm4 Edm5 Epiphyseal Dysplasia, Fairbank Type Epiphyseal Dysplasia, Ribbing Type Multiple Epiphyseal Dysplasia, Autosomal Dominant Multiple Epiphyseal Dysplasia, Autosomal Recessive Rmed Dysplasia, Epiphyseal, Multiple Osteochondrodysplasias
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162284	BAY-9835	Antagonist	99.46%	Unkown
HY-168003	ADAMTS7-IN-1	Inhibitor	98.91%	Unkown
HY-RS00307	ADAMTS7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19830	Adamts7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26327	Adamts7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADAMTS7	MGD	MGI:1347346
Macaca mulatta	ADAMTS7	VGNC	VGNC:82098
Canis familiaris	ADAMTS7	VGNC	VGNC:37603
Rattus norvegicus	ADAMTS7	RGD	RGD:1306713
Bos taurus	ADAMTS7	VGNC	VGNC:57155
Felis catus	ADAMTS7	VGNC	VGNC:82366
Others	ADAMTS7	NCBI