Alox12 - arachidonate 12-lipoxygenase Gene

Also Known as P-12LO; Alox12p; 9930022G08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11684

About Alox12

Chromosome 11: 70,132,283-70,146,179 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in genital fat pad adult (RPKM 9.9), spleen adult (RPKM 9.6) and 19 other tissues.

Summary

Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; and liver right lobe. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 Products (2)

mRNA	Protein	Name
NM_001331118.1	NP_001318047.1	polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2
NM_007440.5	NP_031466.2	polyunsaturated fatty acid lipoxygenase ALOX12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate 12(S)-lipoxygenase activity	IDA IDA: Inferred from direct assay	8188678	MGI
enables arachidonate 12(S)-lipoxygenase activity	IMP IMP: Inferred from mutant phenotype	11256953	MGI
enables linoleate 13S-lipoxygenase activity	IMP IMP: Inferred from mutant phenotype	11256953	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	8188678	MGI
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	9501222	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	10383730	MGI
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	25293588	MGI
involved in lipoxygenase pathway	IDA IDA: Inferred from direct assay	8188678	MGI
involved in lipoxygenase pathway	IMP IMP: Inferred from mutant phenotype	9501222	MGI
involved in negative regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	9501222	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7868854	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox12 Protein Structure

PLAT_LOX

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid lipoxygenase ALOX12	12S-LOX 12S-lipoxygenase arachidonate (12S)-lipoxygenase arachidonate (15S)-lipoxygenase arachidonate 12-lipoxygenase, 12S-type arachidonate 15-lipoxygenase,15S-type linoleate 13S-lipoxygenase lipoxin synthase 12-LO platelet-type lipoxygenase 12

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150191	IMA-1		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113509B	15(R)-Lipoxin A4		98.3%	Unkown
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00618	Alox15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox12	NCBI	NCBI:239