Alox12 - arachidonate 12-lipoxygenase Gene

Mus musculus

Also known as P-12LO; Alox12p; 9930022G08Rik

Gene ID: 11684 | Gene type: protein coding

About Alox12

Chromosome 11: 70,132,283-70,146,179 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in genital fat pad adult (RPKM 9.9), spleen adult (RPKM 9.6) and 19 other tissues.

Summary

Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; and liver right lobe. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 Products(2)

mRNA	Protein	Name
NM_001331118.1	NP_001318047.1	polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2
NM_007440.5	NP_031466.2	polyunsaturated fatty acid lipoxygenase ALOX12 isoform 1

Alox12 Protein Structure

PLAT_LOX

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

polyunsaturated fatty acid lipoxygenase ALOX12

12S-LOX	12S-lipoxygenase
arachidonate (12S)-lipoxygenase	arachidonate (15S)-lipoxygenase
arachidonate 12-lipoxygenase, 12S-type	arachidonate 15-lipoxygenase,15S-type
linoleate 13S-lipoxygenase	lipoxin synthase 12-LO
platelet-type lipoxygenase 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox12	NCBI	NCBI:239

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