2. Gene
  3. JAML - junction adhesion molecule like Gene

JAML - junction adhesion molecule like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMICA; Gm638; AMICA1; CREA7-1; CREA7-4

Gene ID: 120425 | Gene type: protein coding

About JAML

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,193,725-118,225,011 (from NCBI)

This gene has 13 transcripts (splice variants), 39 orthologues and 6 paralogues. Broad expression in appendix (RPKM 34.6), spleen (RPKM 24.5) and 14 other tissues.

Summary

Enables Integrin binding activity and protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and myeloid leukocyte migration. Located in bicellular tight junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

JAML Products(4)

mRNA Protein Name
NM_001098526.2 NP_001091996.1 junctional adhesion molecule-like isoform 1 precursor
NM_001286570.2 NP_001273499.1 junctional adhesion molecule-like isoform 3
NM_001286571.2 NP_001273500.1 junctional adhesion molecule-like isoform 3
NM_153206.3 NP_694938.2 junctional adhesion molecule-like isoform 2

JAML Protein Structure

V-set

V-set: Immunoglobulin V-set domain (25 - 135)

V-set

V-set: Immunoglobulin V-set domain (139 - 251)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

junctional adhesion molecule-like

adhesion molecule AMICA

Recombinant JAML Proteins

Cat. No. Product Name Accession Purity
HY-P75895 JAML/AMICA Protein, Human (HEK293, His) Q86YT9/NP_001091996.1 (L20-L275) ≥95%
HY-P77726 JAML/AMICA Protein, Human (256a.a, HEK293, His) Q86YT9 (L20-L275) ≥95%

Related Diseases

Diseases Alias
Malignant Histiocytic Disease

Histiocytic Disorders, Malignant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07029 JAML Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus JAML VGNC VGNC:82038
Rattus norvegicus JAML RGD RGD:1562572
Bos taurus JAML VGNC VGNC:30370
Mus musculus JAML MGD MGI:2685484
Canis familiaris JAML VGNC VGNC:42180
Macaca mulatta JAML VGNC VGNC:73860
Others JAML NCBI