JAML - junction adhesion molecule like Gene

Also Known as AMICA; Gm638; AMICA1; CREA7-1; CREA7-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 120425

About JAML

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,193,725-118,225,011 (from NCBI)

This gene has 13 transcripts (splice variants), 39 orthologues and 6 paralogues. Broad expression in appendix (RPKM 34.6), spleen (RPKM 24.5) and 14 other tissues.

Summary

Enables Integrin binding activity and protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and myeloid leukocyte migration. Located in bicellular tight junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

JAML Products (4)

mRNA	Protein	Name
NM_001098526.2	NP_001091996.1	junctional adhesion molecule-like isoform 1 precursor
NM_001286570.2	NP_001273499.1	junctional adhesion molecule-like isoform 3
NM_001286571.2	NP_001273500.1	junctional adhesion molecule-like isoform 3
NM_153206.3	NP_694938.2	junctional adhesion molecule-like isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	12869515	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12869515	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12869515	GOA
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	18948633	GOA
involved in monocyte extravasation	IMP IMP: Inferred from mutant phenotype	18948633	GOA
involved in neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	15800062	GOA
involved in neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	15800062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	15800062	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12869515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAML Protein Structure

V-set

0
100
200
300
394 a.a.

Protein Preferred Names	Protein Names
junctional adhesion molecule-like	adhesion molecule AMICA

Recombinant JAML Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75895	JAML/AMICA Protein, Human (HEK293, His)	Q86YT9-1/NP_001091996.1 (L20-L275)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07029	JAML Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17889	Jaml Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24358	Jaml Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	JAML	VGNC	VGNC:82038
Rattus norvegicus	JAML	RGD	RGD:1562572
Bos taurus	JAML	VGNC	VGNC:30370
Mus musculus	JAML	MGD	MGI:2685484
Canis familiaris	JAML	VGNC	VGNC:42180
Macaca mulatta	JAML	VGNC	VGNC:73860
Others	JAML	NCBI