LRIG3 - leucine rich repeats and immunoglobulin like domains 3 Gene

Also Known as LIG3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 121227

About LRIG3

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:58,872,155-58,920,504 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues, 22 paralogues and is associated with 69 phenotypes. Broad expression in thyroid (RPKM 16.5), skin (RPKM 7.2) and 24 other tissues.

Summary

Predicted to act upstream of or within otolith morphogenesis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRIG3 Products (2)

mRNA Protein Name
NM_001136051.3 NP_001129523.1 leucine-rich repeats and immunoglobulin-like domains protein 3 isoform 1 precursor
NM_153377.5 NP_700356.2 leucine-rich repeats and immunoglobulin-like domains protein 3 isoform 2 precursor

LRIG3 Protein Structure

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (122 - 161)

LRR_8

LRR_8: Leucine rich repeat (168 - 227)

LRR_8

LRR_8: Leucine rich repeat (312 - 371)

LRR_8

LRR_8: Leucine rich repeat (387 - 442)

I-set

I-set: Immunoglobulin I-set domain (499 - 599)

I-set

I-set: Immunoglobulin I-set domain (603 - 693)

I-set

I-set: Immunoglobulin I-set domain (697 - 784)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1119 a.a.
Protein Preferred Names Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 3

  • LIG-3

Related Diseases

Diseases Alias
Urofacial Syndrome 1

  • Urofacial Syndrome

  • Ochoa Syndrome

  • Hydronephrosis With Peculiar Facial Expression

  • Ufs

  • Inverted Smile And Occult Neuropathic Bladder

  • Partial Facial Palsy With Urinary Abnormalities

  • UFS1

  • Urofacial Ochoa'S Syndrome

  • Urofacial Syndrome Type 1

  • Facial Palsy, Partial, With Urinary Abnormalities

  • Hydronephrosis-Inverted Smile

  • Inverted Smile-Neurogenic Bladder

  • Hydronephrosis-Inverted Smile Syndrome

  • Inverted Smile-Neurogenic Bladder Syndrome

  • Partial Facial Palsy Partial With Urinary Abnormalities

  • Urologic Diseases
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07789 LRIG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22616 Lrig3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29131 Lrig3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRIG3 VGNC VGNC:63282
Bos taurus LRIG3 VGNC VGNC:30984
Macaca mulatta LRIG3 VGNC VGNC:100073
Mus musculus LRIG3 MGD MGI:2443955
Rattus norvegicus LRIG3 RGD RGD:1561255
Canis familiaris LRIG3 VGNC VGNC:42769
Others LRIG3 NCBI