WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

Also Known as GASP-1; WFDC20B; hGASP-1; WFIKKNRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124857

About WFIKKN2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,834,584-50,842,353 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 13 paralogues. Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8).

Summary

The WFIKKN1 protein contains a WAP domain, Follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, Follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

WFIKKN2 Products (2)

mRNA Protein Name
NM_001330341.2 NP_001317270.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2
NM_175575.6 NP_783165.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18596030 GOA
enables receptor antagonist activity IDA
IDA: Inferred from direct assay
21054789 GOA
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
21054789 GOA
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
12595574 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
21054789 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12595574 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WFIKKN2 Protein Structure

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (42 - 90)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (138 - 168)

I-set

I-set: Immunoglobulin I-set domain (213 - 304)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (328 - 379)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (385 - 436)

NTR

NTR: UNC-6/NTR/C345C module (457 - 559)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
Protein Preferred Names Protein Names

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

  • WAP four-disulfide core domain 20B

Recombinant WFIKKN2 Proteins

Cat. No. Product Name Accession Purity
HY-P75173 GASP-1/WFIKKN2 Protein, Human (HEK293, His) Q8TEU8 (L35-H576) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Space Motion Sickness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15812 WFIKKN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21268 Wfikkn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27786 Wfikkn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WFIKKN2 MGD MGI:2669209
Bos taurus WFIKKN2 VGNC VGNC:55888
Canis familiaris WFIKKN2 VGNC VGNC:104174
Felis catus WFIKKN2 VGNC VGNC:99574
Macaca mulatta WFIKKN2 VGNC VGNC:79900
Rattus norvegicus WFIKKN2 RGD RGD:1305361
Others WFIKKN2 NCBI