CNN2 - calponin 2 Gene

Homo sapiens

Gene ID: 1265 | Gene type: protein coding

About CNN2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,026,608-1,039,065 (from NCBI)

This gene has 12 transcripts (splice variants), 147 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 70.8), appendix (RPKM 62.8) and 24 other tissues.

Summary

The protein encoded by this gene, which can bind actin, Calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

CNN2 Products(4)

mRNA	Protein	Name
NM_001303499.2	NP_001290428.1	calponin-2 isoform c
NM_001303501.2	NP_001290430.1	calponin-2 isoform d
NM_004368.4	NP_004359.1	calponin-2 isoform a
NM_201277.3	NP_958434.1	calponin-2 isoform b

Protein Preferred Names

Protein Names

calponin-2

calponin H2, smooth muscle

Related Diseases

Diseases

Alias

Spastic Paraplegia 77, Autosomal Recessive

SPG77	Hereditary Spastic Paraplegia 77
Autosomal Recessive Spastic Paraplegia 77	Autosomal Recessive Spastic Paraplegia Type 77

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02893	CNN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNN2	VGNC	VGNC:109603
Bos taurus	CNN2	VGNC	VGNC:27509
Canis familiaris	CNN2	VGNC	VGNC:57307
Mus musculus	CNN2	MGD	MGI:105093
Rattus norvegicus	CNN2	RGD	RGD:1589807
Others	CNN2	NCBI