CNN2 - calponin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1265

About CNN2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,026,608-1,039,065 (from NCBI)

This gene has 12 transcripts (splice variants), 147 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 70.8), appendix (RPKM 62.8) and 24 other tissues.

Summary

The protein encoded by this gene, which can bind actin, Calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

CNN2 Products (4)

mRNA Protein Name
NM_001303499.2 NP_001290428.1 calponin-2 isoform c
NM_001303501.2 NP_001290430.1 calponin-2 isoform d
NM_004368.4 NP_004359.1 calponin-2 isoform a
NM_201277.3 NP_958434.1 calponin-2 isoform b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
16236705 GOA
acts upstream of or within regulation of actin filament-based process IDA
IDA: Inferred from direct assay
16236705 GOA
Cellular Component GO Annotation Evidence References Source
located in stress fiber IDA
IDA: Inferred from direct assay
16236705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calponin-2

  • calponin H2, smooth muscle

Related Diseases

Diseases Alias
Spastic Paraplegia 77, Autosomal Recessive

  • SPG77

  • Hereditary Spastic Paraplegia 77

  • Autosomal Recessive Spastic Paraplegia 77

  • Autosomal Recessive Spastic Paraplegia Type 77
Granulomatous Amebic Encephalitis

  • Granulomatous Amoebic Encephalitis

  • Acanthamoeba Encephalitis

  • Acanthamoeba Granulomatous Encephalitis

  • Granulomatous Amebic Encephalitis Due To Acanthamoeba
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D2976 CN-N2 / Unkown
HY-RS02893 CNN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22128 Cnn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28650 Cnn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CNN2 VGNC VGNC:109603
Bos taurus CNN2 VGNC VGNC:27509
Canis familiaris CNN2 VGNC VGNC:57307
Mus musculus CNN2 MGD MGI:105093
Rattus norvegicus CNN2 RGD RGD:1589807
Others CNN2 NCBI