Cyp24a1 - cytochrome P450, family 24, subfamily a, polypeptide 1 Gene

Also Known as CP24; Cyp24; 24-OHase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13081

Summary

The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]

Cyp24a1 Products (1)

mRNA Protein Name
NM_009996.4 NP_034126.1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 25-hydroxycholecalciferol-24-hydroxylase activity IMP
IMP: Inferred from mutant phenotype
15225763 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within vitamin D metabolic process IMP
IMP: Inferred from mutant phenotype
15225763 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

  • 25-hydroxyvitamin D-24-hydroxylase

  • cytochrome P450 24A1

  • cytochrome P450, 24

  • cytochrome P450, 24a1

  • cytochrome P450-CC24

  • vitamin D(3) 24-hydroxylase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0105 Ketoconazole Inhibitor 99.57% Yes

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-77278 25-Hydroxytachysterol3 Agonist 98.07% Unkown
HY-N10508 Calcitroic acid Ligand 85.0% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-B0105S Ketoconazole-d8 Inhibitor 99.79% Unkown
HY-B0105S1 Ketoconazole-d4 Inhibitor 99.63% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-178336 AC-340 / Unkown
HY-181486 VDR agonist 5 Agonist / Unkown
HY-N10508S Calcitroic acid-13C Ligand / Unkown
HY-RS03446 CYP24A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-166670S Ketoconazole carbonyl-13C Inhibitor / Unkown
HY-RS19541 Cyp24a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26037 Cyp24a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp24a1 NCBI NCBI:1591