KCNH8 - potassium voltage-gated channel subfamily H member 8 Gene

Also Known as ELK; ELK1; elk3; Kv12.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131096

About KCNH8

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:19,148,510-19,535,642 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.2), adrenal (RPKM 1.5) and 13 other tissues.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]

KCNH8 Products (1)

mRNA Protein Name
NM_144633.3 NP_653234.2 potassium voltage-gated channel subfamily H member 8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
11897058 GOA
Biological Process GO Annotation Evidence References Source
involved in potassium ion transport IDA
IDA: Inferred from direct assay
11897058 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNH8 Protein Structure

PAS_9

PAS_9: PAS domain (40 - 135)

Ion_trans

Ion_trans: Ion transport protein (261 - 469)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (572 - 656)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1107 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 8

  • ELK channel 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07131 KCNH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21611 Kcnh8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28129 Kcnh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KCNH8 VGNC VGNC:55057
Macaca mulatta KCNH8 VGNC VGNC:73855
Felis catus KCNH8 VGNC VGNC:63039
Canis familiaris KCNH8 VGNC VGNC:42253
Rattus norvegicus KCNH8 RGD RGD:2549
Mus musculus KCNH8 MGD MGI:2445160