DGKK - diacylglycerol kinase kappa Gene

Homo sapiens

Gene ID: 139189 | Gene type: protein coding

About DGKK

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:50,365,409-50,470,825 (from NCBI)

This gene has 1 transcript (splice variant), 103 orthologues and 9 paralogues. Biased expression in adrenal (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue.

Summary

The protein encoded by this gene is an Enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

DGKK Products(1)

mRNA	Protein	Name
NM_001013742.4	NP_001013764.1	diacylglycerol kinase kappa

Protein Preferred Names

Protein Names

diacylglycerol kinase kappa

142 kDa diacylglycerol kinase

Related Diseases

Diseases

Alias

Hypospadias

Hypospadias Familial

Familial Hypospadias

Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7
NPHS7	Nephrotic Syndrome Type 7
Ig-Mediated Membranoproliferative Glomerulonephritis	Ig-Mediated Mpgn
Immunoglobulin-Mediated Mpgn	Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis
Hemolytic Uremic Syndrome, Atypical 7	Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis
Hemolytic Uremic Syndrome With Dgke Deficiency	Hus With Dgke Deficiency
Hemolytic Uremic Syndrome Atypical 7	AHUS7
Nephrotic Syndrome 7	Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03722	DGKK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DGKK	VGNC	VGNC:56703
Mus musculus	DGKK	MGD	MGI:3580254
Canis familiaris	DGKK	VGNC	VGNC:39922
Felis catus	DGKK	VGNC	VGNC:61462
Macaca mulatta	DGKK	VGNC	VGNC:71823
Rattus norvegicus	DGKK	RGD	RGD:1561510