Tnfrsf1b - TNF receptor superfamily member 1B Gene

Also Known as Tnfr2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 156767

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and varicosity. Used to study visual epilepsy. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF Receptor Superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf1b Products (1)

mRNA Protein Name
NM_130426.4 NP_569110.1 tumor necrosis factor receptor superfamily member 1B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables tumor necrosis factor receptor activity IDA
IDA: Inferred from direct assay
12376316 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
20715153 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
11324713 RGD
involved in immune response IDA
IDA: Inferred from direct assay
12376316 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
21195213 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11240015 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20715153 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20715153 RGD
located in varicosity IDA
IDA: Inferred from direct assay
20715153 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 1B

  • TNF-R2

  • TNF-RII

  • TNFR-II

  • p75

  • p80 TNF-alpha receptor

  • tumor necrosis factor receptor 2

  • tumor necrosis factor receptor superfamily, member 1b

  • tumor necrosis factor receptor type II

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991402 BI-1910 Inhibitor 98.24% Phase 2
HY-P990994 Emunkitug Inhibitor 99.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14811 TNFRSF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174515 Human TNFRSF1B mRNA / Unkown
HY-RS17435 Tnfrsf1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23891 Tnfrsf1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99782 Opinercept Inhibitor / Unkown
HY-P991403 BC011 Inhibitor / Unkown
HY-P991680 Elipunercept / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf1b NCBI NCBI:7133