Kirrel - kirre like nephrin family adhesion molecule 1 Gene

Also Known as Neph1; Kirrel1; 6720469N11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170643

Summary

Predicted to enable cell adhesion molecule binding activity and Myosin binding activity. Acts upstream of or within several processes, including excretion; negative regulation of protein phosphorylation; and positive regulation of actin filament polymerization. Located in cell-cell junction; dendritic shaft; and plasma membrane. Is expressed in craniocervical region bone; glomerular tuft; lung; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Kirrel Products (3)

mRNA Protein Name
NM_001170985.2 NP_001164456.1 kin of IRRE-like protein 1 isoform 1 precursor
NM_001377046.1 NP_001363975.1 kin of IRRE-like protein 1 isoform 2 precursor
NM_130867.4 NP_570937.2 kin of IRRE-like protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17923684 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
21306299 MGI
acts upstream of or within cell-cell adhesion IGI
IGI: Inferred from genetic interaction
21306299 MGI
acts upstream of or within negative regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
21306299 MGI
acts upstream of or within positive regulation of actin filament polymerization IGI
IGI: Inferred from genetic interaction
17923684 MGI
acts upstream of or within renal protein absorption IMP
IMP: Inferred from mutant phenotype
11416156 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
21306299 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
16874800 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17923684 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kin of IRRE-like protein 1

  • kin of IRRE like 1

  • kin of irregular chiasm-like protein 1

  • nephrin 1

  • nephrin-like protein 1

Recombinant Kirrel Proteins

Cat. No. Product Name Accession Purity
HY-P70866 Kirrel1/NEPH1 Protein, Mouse (HEK293, His) Q80W68-1 (L48-L525) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07312 KIRREL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07313 KIRREL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07314 KIRREL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18317 Kirrel1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18723 Kirrel3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20634 Kirrel2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24795 Kirrel1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25210 Kirrel3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27143 Kirrel2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown