LIPH - lipase H Gene

Also Known as AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 200879

About LIPH

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,506,262-185,552,588 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues, 9 paralogues and is associated with 3 phenotypes. Biased expression in colon (RPKM 18.6), stomach (RPKM 18.4) and 12 other tissues.

Summary

This gene encodes a membrane-bound member of the mammalian triglyceride Lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]

LIPH Products (1)

mRNA	Protein	Name
NM_139248.3	NP_640341.1	lipase member H precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparin binding	IDA IDA: Inferred from direct assay	12963729	GOA
enables phospholipase activity	IDA IDA: Inferred from direct assay	12963729	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32336749	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lipid catabolic process	IDA IDA: Inferred from direct assay	12963729	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12963729	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12963729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIPH Protein Structure

Lipase

0
100
200
300
400
451 a.a.

Protein Preferred Names	Protein Names
lipase member H	LPD lipase-related protein

Related Diseases

Diseases	Alias
Hypotrichosis 7	Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis HYPT7 Hypotrichosis, Localized, Autosomal Recessive 2 Lah2 Ah Total Hypotrichosis, Mari Type Wh/Ht Hypotrichosis, Autosomal Recessive Hypotrichosis, Total, Mari Type Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis Total Mari Type Hypotrichosis Alopecia Universalis Congenita, Mari Type Mari Type Alopecia Universalis Congenita Autosomal Recessive Hypotrichosis Autosomal Recessive Localized Hypotrichosis Autosomal Recessive Woolly Hair With Or Without Hypotrichosis Htl Hypotrichoses Hypotrichosis Lah Alopecia Universalis Congenita Mari Type Hypotrichosis Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 2 Total Hypotrichosis Mari Type Woolly Hair Autosomal Recessive 2 ARWH2 Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Hypotrichosis Simplex	Hereditary Hypotrichosis Simplex Hhs
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Hypotrichosis
Woolly Hair, Autosomal Dominant	Autosomal Dominant Woolly Hair ADWH Woolly Hair Autosomal Dominant
Hypotrichosis 13	HYPT13 Hypotrichosis With Woolly Hair Hypotrichosis, Type 13
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Woolly Hair, Autosomal Recessive 3	ARWH3 Woolly Hair, Autosomal Recessive 3, With Hypotrichosis Autosomal Recessive Woolly Hair 3 Woolly Hair Autosomal Recessive 3
Hypotrichosis 3	HYPT3 Hypotrichosis Simplex Of The Scalp 2 Htss2 Hypotrichosis, Type 3
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Hypotrichosis 4	HYPT4 Marie Unna Hereditary Hypotrichosis 1 Muhh1 Hypotrichosis, Marie Unna Type, 1 Hypotrichosis Marie Unna 1 Marie Unna Hereditary Hypotrichosis Type 1 Hypotrichosis, Hereditary, Marie Unna Type, 1 Hypotrichosis, Type 4
Hypotrichosis 11	HYPT11 Hypotrichosis, Type 11
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Hypotrichosis 6	HYPT6 Lah1 Hypotrichosis, Localized, Autosomal Recessive Monilethrix-Like Hypotrichosis Hypotrichosis, Localized, Autosomal Recessive 1 Lah Htl Autosomal Recessive Localized Hypotrichosis Hypotrichosis Localized Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 1 Hypotrichosis, Type 6
Hypotrichosis, Congenital, With Juvenile Macular Dystrophy	HJMD Congenital Hypotrichosis With Juvenile Macular Dystrophy Hypotrichosis With Cone-Rod Dystrophy Hypotrichosis With Juvenile Macular Dystrophy Juvenile Macular Degeneration And Hypotrichosis Juvenile Macular Dystrophy And Congenital Hypotrichosis Hypotrichosis With Juvenile Macular Degeneration Hypotrichosis Congenital With Juvenile Macular Dystrophy
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly	MARCH Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia And Hydranencephaly Multinucleated Neurons-Anhydramnios-Renal Dysplasia-Cerebellar Hypoplasia-Hydranencephaly Syndrome Hydranencephaly With Renal Aplasia-Dysplasia March Syndrome
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Diffuse Alopecia Areata	Diffuse Alopecia
Hypotrichosis 1	HYPT1 Hhs Hts Hypotrichosis Simplex Hypotrichosis Simplex, Generalized, Hereditary Hereditary Generalized Hypotrichosis Simplex Generalized Hypothricosis Simplex Hypotrichosis Simplex Hereditary Hypotrichosis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07690	LIPH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07686	LIPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20294	Liph Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26802	Liph Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LIPH	MGD	MGI:2388029
Felis catus	LIPH	VGNC	VGNC:63239
Rattus norvegicus	LIPH	RGD	RGD:1592849
Canis familiaris	LIPH	VGNC	VGNC:42697
Bos taurus	LIPH	VGNC	VGNC:30905
Others	LIPH	NCBI