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Sema5a - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Gene

Also Known as semF; Semaf; 5930434A13; 9130201M22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20356

Summary

Enables axon guidance receptor activity and semaphorin receptor binding activity. Involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of endothelial cell apoptotic process; and regulation of signal transduction. Acts upstream of or within axonogenesis; branching involved in blood vessel morphogenesis; and detection of light stimulus involved in visual perception. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA5A (semaphorin 5A). [provided by Alliance of Genome Resources, Apr 2022]

Sema5a Products (1)

mRNA	Protein	Name
NM_009154.2	NP_033180.2	semaphorin-5A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables axon guidance receptor activity	IDA IDA: Inferred from direct assay	12506007	MGI
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	15218527	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon extension	IGI IGI: Inferred from genetic interaction	21835343	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12506007	MGI
involved in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	19850054	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15743826	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15743826	MGI
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	15218527	MGI
acts upstream of or within detection of light stimulus involved in visual perception	IGI IGI: Inferred from genetic interaction	21835343	MGI
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	15218527	MGI
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	19850054	MGI
acts upstream of or within neuron projection extension	IDA IDA: Inferred from direct assay	21835343	MGI
acts upstream of or within neuron projection extension	IGI IGI: Inferred from genetic interaction	21835343	MGI
acts upstream of or within neuron projection guidance	IGI IGI: Inferred from genetic interaction	21835343	MGI
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	15218527	MGI
involved in positive regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	19850054	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	19850054	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19850054	MGI
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	19850054	MGI
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19850054	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19850054	MGI
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	15218527	MGI
involved in signal clustering	IDA IDA: Inferred from direct assay	15218527	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	12506007	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
semaphorin-5A	M-Sema D sema F semaphorin F

Recombinant Sema5a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74559	Semaphorin-5A/SEMA5A Protein, Mouse (HEK293, His)	Q3UPZ0 (E23-T765)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12663	SEMA5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19268	Sema5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25757	Sema5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema5a	NCBI	NCBI:9037