F2R - coagulation factor II thrombin receptor Gene

Also Known as TR; HTR; CF2R; PAR1; PAR-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2149

About F2R

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,716,126-76,735,770 (from NCBI)

This gene has 2 transcripts (splice variants), 330 orthologues and 16 paralogues. Ubiquitous expression in spleen (RPKM 37.1), gall bladder (RPKM 26.8) and 21 other tissues.

Summary

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

F2R Products (2)

mRNA	Protein	Name
NM_001992.5	NP_001983.2	proteinase-activated receptor 1 isoform 1 precursor
NM_001311313.2	NP_001298242.1	proteinase-activated receptor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17299037	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	1672265	GOA
enables thrombin-activated receptor activity	IDA IDA: Inferred from direct assay	1672265	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10692450	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in connective tissue replacement involved in inflammatory response wound healing	IDA IDA: Inferred from direct assay	9639571	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10692450	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20164183	GOA
involved in platelet activation	IDA IDA: Inferred from direct assay	9038223	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17848177	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	17848177	GOA
involved in positive regulation of blood coagulation	IDA IDA: Inferred from direct assay	9038223	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	9701242	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	9639571	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10692450	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	11447194	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	17404307	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	1672265	GOA
involved in regulation of blood coagulation	IDA IDA: Inferred from direct assay	17848177	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	9639571	GOA
involved in thrombin-activated receptor signaling pathway	IDA IDA: Inferred from direct assay	1672265	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	17848177	GOA
located in cell surface	IDA IDA: Inferred from direct assay	24732013	GOA
located in early endosome	IDA IDA: Inferred from direct assay	22547407	GOA
located in late endosome	IDA IDA: Inferred from direct assay	24732013	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9038223	GOA
located in platelet dense tubular network	IDA IDA: Inferred from direct assay	9038223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2R Protein Structure

7tm_1

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
proteinase-activated receptor 1	protease-activated receptor 1

F2R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	F2R	P25116	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	20826780
Intra	F2R	P25116	PROCR	Homo sapiens	Q9UNN8	Anti Bait CoIP	20826780

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant F2R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73612	Thrombin Receptor/PAR1 Protein, Human (HEK293, His)	P25116/NP_001983.2 (A22-T102)	≥ 95%, as determined by reducing SDS-PAGE.

F2R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84211	PAR1 Antibody (YA3908)	IHC-P, ELISA	Human
HY-P84211A	PAR1 Antibody (YA3908)(PBS only)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Thrombosis	Thrombosis Of Blood Vessel
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Chromosome 5q Deletion Syndrome	5q- Syndrome Mar Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic 5q Deletion Syndrome 5q Minus Syndrome Refractory Macrocytic Anemia Due To 5q Deletion Myelodysplastic Syndrome With Isolated Del Macrocytic Anemia, Refractory, Due To 5q Deletion 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion 5q Syndrome Chromosome 5q Deletion Myelodysplastic Syndrome With 5q Deletion Myelodysplastic Syndrome With 5q Deletion Syndrome Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic 5q-Syndrome Chromosome 5, Trisomy 5q Loss Of Chromosome 5q 5 Q- Syndrome
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Peripheral Artery Disease	Peripheral Arterial Disease Peripheral Arterial Diseases
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Glanzmann'S Thrombasthenia Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Pulmonary Fibrosis	Fibrosis Of Lung
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Bleeding Disorder, Platelet-Type, 20	Platelet-Type Bleeding Disorder 20 BDPLT20 Autosomal Dominant Thrombocytopenia With Platelet Secretion Defect
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Alpha-2-Plasmin Inhibitor Deficiency	Plasmin Inhibitor Deficiency Antiplasmin Deficiency Antiplasmin Defiency Anti-Plasmin Deficiency, Congenital Antiplasmin Deficiency, Congenital Congenital Alpha2-Antiplasmin Deficiency APLID Congenital Alpha2 Antiplasmin Deficiency
Carotid Artery Thrombosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04631	F2R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04632	F2r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04633	F2r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	F2R	VGNC	VGNC:40548
Rattus norvegicus	F2R	RGD	RGD:2586
Macaca mulatta	F2R	VGNC	VGNC:84374
Felis catus	F2R	VGNC	VGNC:62024
Bos taurus	F2R	VGNC	VGNC:28683
Mus musculus	F2R	MGD	MGI:101802
Others	F2R	NCBI