Tnnt2 - troponin T2, cardiac Gene

Also Known as Tnt; cTnT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21956

Summary

A structural constituent of Cytoskeleton. Acts upstream of or within several processes, including cardiac muscle tissue morphogenesis; response to bacterium; and sarcomere organization. Located in sarcomere. Part of troponin complex. Is expressed in several structures, including crus of diaphragm; embryo mesenchyme; heart; musculature; and urogenital sinus. Used to study dilated cardiomyopathy 1D and hypertrophic cardiomyopathy 2. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]

Tnnt2 Products (9)

mRNA Protein Name
NM_001130174.2 NP_001123646.1 troponin T, cardiac muscle isoform a
NM_001130175.2 NP_001123647.4 troponin T, cardiac muscle isoform g
NM_001130176.1 NP_001123648.1 troponin T, cardiac muscle isoform b
NM_001130177.2 NP_001123649.1 troponin T, cardiac muscle isoform c
NM_001130178.2 NP_001123650.1 troponin T, cardiac muscle isoform d
NM_001130179.2 NP_001123651.4 troponin T, cardiac muscle isoform h
NM_001130180.2 NP_001123652.1 troponin T, cardiac muscle isoform e
NM_001130181.2 NP_001123653.4 troponin T, cardiac muscle isoform i
NM_011619.3 NP_035749.1 troponin T, cardiac muscle isoform f

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
12832403 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within atrial cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
10449439 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
9637714 MGI
acts upstream of or within muscle contraction IDA
IDA: Inferred from direct assay
12832403 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
11158969 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
10449439 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
16326803 MGI
Cellular Component GO Annotation Evidence References Source
located in myofibril IDA
IDA: Inferred from direct assay
10449439 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
12738802 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
15830381 MGI
part of troponin complex IDA
IDA: Inferred from direct assay
12832403 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

troponin T, cardiac muscle

  • cardiac TnT

  • cardiac muscle troponin T

  • tnTc

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14855 TNNT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22869 Tnnt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29383 Tnnt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnnt2 NCBI NCBI:7139