OTUD1 - OTU deubiquitinase 1 Gene

Also Known as DUBA7; OTDC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 220213

About OTUD1

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,439,075-23,442,377 (from NCBI)

This gene has 1 transcript (splice variant), 156 orthologues and 5 paralogues.

Summary

Deubiquitinating Enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

OTUD1 Products (1)

mRNA Protein Name
NM_001145373.3 NP_001138845.1 OTU domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
Biological Process GO Annotation Evidence References Source
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD1 Protein Structure

OTU

OTU: OTU-like cysteine protease (316 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 1

  • DUBA-7

Related Diseases

Diseases Alias
Acquired Hyperkeratosis

  • Acquired Keratoderma

  • Keratoderma - Acquired

  • Keratoderma, Acquired

  • Keratosis Blennorrhagica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09871 OTUD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18830 Otud1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25321 Otud1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OTUD1 VGNC VGNC:75685
Canis familiaris OTUD1 VGNC VGNC:44184
Mus musculus OTUD1 MGD MGI:1918448
Rattus norvegicus OTUD1 RGD RGD:1563344
Bos taurus OTUD1 VGNC VGNC:32493
Others OTUD1 NCBI