Ube2a - ubiquitin-conjugating enzyme E2A Gene

Also Known as HR6A; HHR6A; Mhr6a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22209

Summary

Enables ubiquitin conjugating enzyme activity and ubiquitin protein Ligase binding activity. Acts upstream of or within blastocyst hatching; maternal process involved in female pregnancy; and protein ubiquitination. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; female reproductive system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to human UBE2A (ubiquitin conjugating enzyme E2 A). [provided by Alliance of Genome Resources, Apr 2022]

Ube2a Products (2)

mRNA Protein Name
NM_001313696.1 NP_001300625.1 ubiquitin-conjugating enzyme E2 A isoform 2
NM_019668.4 NP_062642.1 ubiquitin-conjugating enzyme E2 A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12509447 MGI
enables ubiquitin conjugating enzyme activity IGI
IGI: Inferred from genetic interaction
17462990 MGI
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
17462990 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
27869233 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
15169909 MGI
NOT acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15169909 MGI
acts upstream of or within maternal process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
15169909 MGI
involved in positive regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
23685073 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
25023518 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
15383616 MGI
located in chromatin IDA
IDA: Inferred from direct assay
15383616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 A

  • E2 ubiquitin-conjugating enzyme A

  • RAD6 homolog A

  • ubiquitin carrier protein A

  • ubiquitin-conjugating enzyme E2A (RAD6 homolog)

  • ubiquitin-conjugating enzyme HR6A

  • ubiquitin-protein ligase A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15336 UBE2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18553 Ube2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25035 Ube2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ube2a NCBI NCBI:7319