Zic2 - zinc finger protein of the cerebellum 2 Gene

Also Known as Ku; HPE5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22772

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in regulation of transcription, DNA-templated; retinal ganglion cell axon guidance; and visual perception. Acts upstream of or within several processes, including cilium organization; nervous system development; and positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and neural ectoderm. Used to study holoprosencephaly 5 and schizophrenia. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Zic2 Products (1)

mRNA Protein Name
NM_009574.3 NP_033600.3 zinc finger protein ZIC 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15465018 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11053430 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11053430 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11053430 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18298960 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
20676059 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11238441 MGI
Biological Process GO Annotation Evidence References Source
involved in axial mesoderm development IGI
IGI: Inferred from genetic interaction
17490632 MGI
acts upstream of or within central nervous system development IGI
IGI: Inferred from genetic interaction
11756505 MGI
involved in central nervous system segmentation IGI
IGI: Inferred from genetic interaction
17490632 MGI
acts upstream of or within cilium organization IMP
IMP: Inferred from mutant phenotype
24585447 MGI
acts upstream of or within developmental pigmentation IMP
IMP: Inferred from mutant phenotype
10932191 MGI
involved in gene expression IGI
IGI: Inferred from genetic interaction
17490632 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
21211521 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11053430 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
10677508 MGI
acts upstream of or within neural crest cell differentiation IMP
IMP: Inferred from mutant phenotype
15384171 MGI
involved in neural plate development IGI
IGI: Inferred from genetic interaction
17490632 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15384171 MGI
acts upstream of or within nodal signaling pathway IMP
IMP: Inferred from mutant phenotype
24585447 MGI
involved in paraxial mesoderm development IGI
IGI: Inferred from genetic interaction
17490632 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20676059 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15465018 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11053430 MGI
involved in retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
13678579 MGI
involved in visual perception IMP
IMP: Inferred from mutant phenotype
13678579 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15207726 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11238441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein ZIC 2

  • GENA 29

  • Zic family member 2 (odd-paired homolog, Drosophila)

  • kumba

  • odd-paired homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16074 ZIC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20352 Zic2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26861 Zic2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zic2 NCBI NCBI:7546