2. Gene
  3. SULF1 - sulfatase 1 Gene

SULF1 - sulfatase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SULF-1

Gene ID: 23213 | Gene type: protein coding

About SULF1

Cytogenetic location: 8q13.2-q13.3 Genomic coordinates (GRCh38): 8:69,466,781-69,660,912 (from NCBI)

This gene has 23 transcripts (splice variants), 224 orthologues and 16 paralogues. Broad expression in urinary bladder (RPKM 23.6), prostate (RPKM 21.2) and 19 other tissues.

Summary

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded Enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The Enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of Cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SULF1 Products(27)

mRNA Protein Name
NM_001128204.2 NP_001121676.1 extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001128205.2 NP_001121677.1 extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001128206.2 NP_001121678.1 extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001412828.1 NP_001399757.1 extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412829.1 NP_001399758.1 extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412830.1 NP_001399759.1 extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412831.1 NP_001399760.1 extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412832.1 NP_001399761.1 extracellular sulfatase Sulf-1 isoform 3 precursor
NM_001412833.1 NP_001399762.1 extracellular sulfatase Sulf-1 isoform 4 precursor
NM_001412834.1 NP_001399763.1 extracellular sulfatase Sulf-1 isoform 4 precursor
NM_001412835.1 NP_001399764.1 extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001412836.1 NP_001399765.1 extracellular sulfatase Sulf-1 isoform 5 precursor
NM_001412837.1 NP_001399766.1 extracellular sulfatase Sulf-1 isoform 5 precursor
NM_001412838.1 NP_001399767.1 extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412839.1 NP_001399768.1 extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412840.1 NP_001399769.1 extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412841.1 NP_001399770.1 extracellular sulfatase Sulf-1 isoform 7
NM_001412842.1 NP_001399771.1 extracellular sulfatase Sulf-1 isoform 7
NM_001412844.1 NP_001399773.1 extracellular sulfatase Sulf-1 isoform 9
NM_001412845.1 NP_001399774.1 extracellular sulfatase Sulf-1 isoform 9
NM_001412846.1 NP_001399775.1 extracellular sulfatase Sulf-1 isoform 10
NM_001412847.1 NP_001399776.1 extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412848.1 NP_001399777.1 extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412849.1 NP_001399778.1 extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412850.1 NP_001399779.1 extracellular sulfatase Sulf-1 isoform 7 precursor
NM_001412851.1 NP_001399780.1 extracellular sulfatase Sulf-1 isoform 7 precursor
NM_015170.3 NP_055985.2 extracellular sulfatase Sulf-1 isoform 1 precursor

SULF1 Protein Structure

Sulfatase

Sulfatase: Sulfatase (43 - 374)

DUF3740

DUF3740: Sulfatase protein (533 - 680)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 871 a.a.
Protein Preferred Names Protein Names

extracellular sulfatase Sulf-1

sulfatase FP

Related Diseases

Diseases Alias
Mesomelia-Synostoses Syndrome

Mesomelic Dysplasia With Acral Synostoses, Verloes-David-Pfeiffer Type

Verloes-David Syndrome

Chromosome 8q13 Deletion Syndrome

Mesomelic Dysplasia, Syndromic

Dominant Mesomelic Shortness Of Stature With Acral Synostoses, Umbilical Anomalies, And Soft Palate Agenesis

Mesomelia Synostoses

8q13 Microdeletion Syndrome

Del(8)Q(13)

Mesomelia-Synostoses Syndrome, Verloes-David-Pfeiffer Type

Monosomy 8q13
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14011 SULF1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SULF1 MGD MGI:2138563
Felis catus SULF1 VGNC VGNC:65833
Rattus norvegicus SULF1 RGD RGD:708554
Bos taurus SULF1 VGNC VGNC:53880
Canis familiaris SULF1 VGNC VGNC:46974
Macaca mulatta SULF1 VGNC VGNC:78178