SULF1 - sulfatase 1 Gene

Also Known as SULF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23213

About SULF1

Cytogenetic location: 8q13.2-q13.3 Genomic coordinates (GRCh38): 8:69,466,781-69,660,912 (from NCBI)

This gene has 23 transcripts (splice variants), 224 orthologues and 16 paralogues. Broad expression in urinary bladder (RPKM 23.6), prostate (RPKM 21.2) and 19 other tissues.

Summary

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of Cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SULF1 Products (27)

mRNA	Protein	Name
NM_001128204.2	NP_001121676.1	extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001128205.2	NP_001121677.1	extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001128206.2	NP_001121678.1	extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001412828.1	NP_001399757.1	extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412829.1	NP_001399758.1	extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412830.1	NP_001399759.1	extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412831.1	NP_001399760.1	extracellular sulfatase Sulf-1 isoform 2 precursor
NM_001412832.1	NP_001399761.1	extracellular sulfatase Sulf-1 isoform 3 precursor
NM_001412833.1	NP_001399762.1	extracellular sulfatase Sulf-1 isoform 4 precursor
NM_001412834.1	NP_001399763.1	extracellular sulfatase Sulf-1 isoform 4 precursor
NM_001412835.1	NP_001399764.1	extracellular sulfatase Sulf-1 isoform 1 precursor
NM_001412836.1	NP_001399765.1	extracellular sulfatase Sulf-1 isoform 5 precursor
NM_001412837.1	NP_001399766.1	extracellular sulfatase Sulf-1 isoform 5 precursor
NM_001412838.1	NP_001399767.1	extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412839.1	NP_001399768.1	extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412840.1	NP_001399769.1	extracellular sulfatase Sulf-1 isoform 6 precursor
NM_001412841.1	NP_001399770.1	extracellular sulfatase Sulf-1 isoform 7
NM_001412842.1	NP_001399771.1	extracellular sulfatase Sulf-1 isoform 7
NM_001412844.1	NP_001399773.1	extracellular sulfatase Sulf-1 isoform 9
NM_001412845.1	NP_001399774.1	extracellular sulfatase Sulf-1 isoform 9
NM_001412846.1	NP_001399775.1	extracellular sulfatase Sulf-1 isoform 10
NM_001412847.1	NP_001399776.1	extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412848.1	NP_001399777.1	extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412849.1	NP_001399778.1	extracellular sulfatase Sulf-1 isoform 11 precursor
NM_001412850.1	NP_001399779.1	extracellular sulfatase Sulf-1 isoform 7 precursor
NM_001412851.1	NP_001399780.1	extracellular sulfatase Sulf-1 isoform 7 precursor
NM_015170.3	NP_055985.2	extracellular sulfatase Sulf-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N-acetylglucosamine-6-sulfatase activity	IDA IDA: Inferred from direct assay	12686563	GOA
enables N-acetylglucosamine-6-sulfatase activity	IMP IMP: Inferred from mutant phenotype	19520866	GOA
enables arylsulfatase activity	IDA IDA: Inferred from direct assay	12368295	GOA
enables arylsulfatase activity	IMP IMP: Inferred from mutant phenotype	19520866	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heparan sulfate proteoglycan metabolic process	IDA IDA: Inferred from direct assay	18687675	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	16778174	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21266348	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	16778174	GOA
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20479257	GOA
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20479257	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	19520866	GOA
involved in regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21266348	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	16778174	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	12368295	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18687675	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19666466	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	19520866	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULF1 Protein Structure

Sulfatase

DUF3740

0
200
400
600
800
871 a.a.

Protein Preferred Names	Protein Names
extracellular sulfatase Sulf-1	sulfatase FP

Related Diseases

Diseases	Alias
Mesomelia-Synostoses Syndrome	Mesomelic Dysplasia With Acral Synostoses, Verloes-David-Pfeiffer Type Verloes-David Syndrome Chromosome 8q13 Deletion Syndrome Mesomelic Dysplasia, Syndromic Dominant Mesomelic Shortness Of Stature With Acral Synostoses, Umbilical Anomalies, And Soft Palate Agenesis Mesomelia Synostoses 8q13 Microdeletion Syndrome Del(8)Q(13) Mesomelia-Synostoses Syndrome, Verloes-David-Pfeiffer Type Monosomy 8q13
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14011	SULF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19746	Sulf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26243	Sulf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SULF1	MGD	MGI:2138563
Felis catus	SULF1	VGNC	VGNC:65833
Rattus norvegicus	SULF1	RGD	RGD:708554
Bos taurus	SULF1	VGNC	VGNC:53880
Canis familiaris	SULF1	VGNC	VGNC:46974
Macaca mulatta	SULF1	VGNC	VGNC:78178
Others	SULF1	NCBI