Itga8 - integrin alpha 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 241226

Summary

This gene encodes a member of the Integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and Other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional Integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of Animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]

Itga8 Products (4)

mRNA Protein Name
NM_001001309.4 NP_001001309.1 integrin alpha-8 isoform 1 preproprotein
NM_001408100.1 NP_001395029.1 integrin alpha-8 isoform 2 preproprotein
NM_001408101.1 NP_001395030.1 integrin alpha-8 isoform 3 precursor
NM_001408102.1 NP_001395031.1 integrin alpha-8 isoform 4 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell projection organization IMP
IMP: Inferred from mutant phenotype
10742111 MGI
involved in establishment of protein localization IMP
IMP: Inferred from mutant phenotype
21335239 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
10742111 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10742111 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
12904471 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
17537792 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
17537792 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17537792 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17537792 MGI
involved in smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
21335239 MGI
involved in smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
21335239 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17537792 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17537792 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
10742111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06955 ITGA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19450 Itga8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25942 Itga8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga8 NCBI NCBI:8516