ITGA8 - integrin subunit alpha 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8516

About ITGA8

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,513,954-15,719,922 (from NCBI)

This gene has 3 transcripts (splice variants), 228 orthologues, 17 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 17.7), lung (RPKM 11.8) and 17 other tissues.

Summary

Integrins are heterodimeric transmembrane Receptor Proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric Integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The Integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

ITGA8 Products (2)

mRNA Protein Name
NM_001291494.2 NP_001278423.1 integrin alpha-8 isoform 2 preproprotein
NM_003638.3 NP_003629.2 integrin alpha-8 isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24439109 GOA
involved in kidney development IMP
IMP: Inferred from mutant phenotype
24439109 GOA
involved in mesodermal cell differentiation IEP
IEP: Inferred from expression pattern
23154389 GOA
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
24439109 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
24439109 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24439109 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA8 Protein Structure

FG-GAP

FG-GAP: FG-GAP repeat (321 - 363)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (483 - 934)

Integrin_alpha

Integrin_alpha: Integrin alpha cytoplasmic region (1035 - 1049)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1063 a.a.
Protein Preferred Names Protein Names

integrin alpha-8

  • integrin, alpha 8

Recombinant ITGA8 Proteins

Cat. No. Product Name Accession Purity
HY-P73869 Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His) P53708 (F39-L1012)&P05556-1 (Q21-D728) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Renal Agenesis, Bilateral

  • Bilateral Renal Agenesis
Bilateral Renal Aplasia
Kidney Disease

  • Renal Failure

  • Kidney Failure

  • Kidney Diseases

  • Nephropathy

  • Abnormality Of The Kidney

  • Impaired Renal Function Disease

  • Renal Anomaly

  • Kidney Dysfunction

  • Renal Disease

  • Nephropathies

  • Renal Failure Adverse Event

  • Abnormal Renal Function
Posterolateral Myocardial Infarction
Bullous Keratopathy

  • Bk - [Bullous Keratopathy]
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1

  • Arrhythmogenic Right Ventricular Dysplasia 1

  • Uhl Anomaly

  • Arrhythmogenic Right Ventricular Cardiomyopathy 1

  • Arvc1

  • ARVD1

  • Cardiomyopathy Right Ventricular Dilated

  • Dysplasia, Arrhythmogenic Right Ventricular, Type 1
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06955 ITGA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19450 Itga8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25942 Itga8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ITGA8 VGNC VGNC:42130
Mus musculus ITGA8 MGD MGI:109442
Macaca mulatta ITGA8 VGNC VGNC:73782
Felis catus ITGA8 VGNC VGNC:67846
Rattus norvegicus ITGA8 RGD RGD:621634
Bos taurus ITGA8 VGNC VGNC:30319
Others ITGA8 NCBI