Atp7a - ATPase copper transporting alpha Gene

Also Known as Mnk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24941

Summary

This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent Enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Nov 2009]

Atp7a Products (1)

mRNA Protein Name
NM_052803.2 NP_434690.1 copper-transporting ATPase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
23349186 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
20671235 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
26722473 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
23814049 RGD
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
17584760 RGD
involved in cellular response to cobalt ion IEP
IEP: Inferred from expression pattern
23814049 RGD
involved in cellular response to copper ion IDA
IDA: Inferred from direct assay
20671235 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
23174565 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
21346155 RGD
involved in cellular response to iron ion IEP
IEP: Inferred from expression pattern
19679821 RGD
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
24316150 RGD
involved in cellular response to platelet-derived growth factor stimulus IMP
IMP: Inferred from mutant phenotype
20671235 RGD
involved in copper ion export IMP
IMP: Inferred from mutant phenotype
22442359 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
28089327 RGD
involved in in utero embryonic development IEP
IEP: Inferred from expression pattern
10864443 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
16741141 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
25349135 RGD
involved in negative regulation of iron ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24174620 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
26722473 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
25156967 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
20671235 RGD
involved in positive regulation of response to wounding IMP
IMP: Inferred from mutant phenotype
20671235 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
20671235 RGD
involved in regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
26722473 RGD
involved in response to copper ion IDA
IDA: Inferred from direct assay
17158254 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
15591161 RGD
involved in response to iron(III) ion IEP
IEP: Inferred from expression pattern
16629162 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
25579025 RGD
involved in response to manganese ion IDA
IDA: Inferred from direct assay
24614235 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
24614235 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
12840169 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15634787 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16081413 RGD
located in axon IDA
IDA: Inferred from direct assay
15634787 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16081413 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
16081413 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
23349186 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15634787 RGD
located in late endosome IDA
IDA: Inferred from direct assay
16741141 RGD
located in membrane IDA
IDA: Inferred from direct assay
12488345 RGD
located in microvillus IDA
IDA: Inferred from direct assay
24614235 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
20836889 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17158254 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
16185750 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12488345 RGD
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
15634787 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

copper-transporting ATPase 1

  • ATPase, Cu++ transporting, alpha polypeptide

  • copper pump 1

  • menkes disease-associated protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01235 ATP7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17972 Atp7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D3282 CCF1 / Unkown
HY-RS17601 Atp7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24443 Atp7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp7a NCBI NCBI:538