Chrna3 - cholinergic receptor nicotinic alpha 3 subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25101

Summary

Enables acetylcholine binding activity; heterocyclic compound binding activity; and postsynaptic neurotransmitter receptor activity. Involved in several processes, including acetylcholine receptor signaling pathway; regulation of synaptic vesicle exocytosis; and response to nicotine. Located in several cellular components, including neuronal cell body; plasma membrane raft; and postsynaptic density. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is integral component of postsynaptic specialization membrane. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna3 Products (1)

mRNA Protein Name
NM_052805.3 NP_434692.2 neuronal acetylcholine receptor subunit alpha-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine binding IDA
IDA: Inferred from direct assay
11297818 RGD
enables acetylcholine receptor activity IDA
IDA: Inferred from direct assay
2444984 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
21540349 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11297818 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
15016836 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
15016836 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20796176 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21540349 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15549397 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
12065717 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12065717 RGD
involved in response to acetylcholine IGI
IGI: Inferred from genetic interaction
21540349 RGD
involved in response to carbon monoxide IEP
IEP: Inferred from expression pattern
24704181 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
17105949 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
15896488 RGD
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
20796176 RGD
part of acetylcholine-gated channel complex IGI
IGI: Inferred from genetic interaction
21540349 RGD
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
3380297 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11297818 RGD
is active in dopaminergic synapse EXP
EXP: Inferred from Experiment
12065717 RGD
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
12065717 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11297818 RGD
located in plasma membrane raft IGI
IGI: Inferred from genetic interaction
21540349 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
3380297 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16129735 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-3

  • Acetylcholine receptor alpha 3 (neuronal nicotine)

  • acetylcholine receptor alpha3

  • cetylcholine receptor alpha 3 (neuronal nicotine)

  • cholinergic receptor nicotinic alpha polypeptide 4

  • cholinergic receptor, nicotinic, alpha 3 (neuronal)

  • cholinergic rece

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02668 CHRNA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20143 Chrna3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26647 Chrna3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna3 NCBI NCBI:1136