FUT5 - fucosyltransferase 5 Gene

Also Known as FUC-TV

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2527

About FUT5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,865,826-5,870,540 (from NCBI)

This gene has 2 transcripts (splice variants), 382 orthologues and 7 paralogues. Biased expression in colon (RPKM 6.2), esophagus (RPKM 5.3) and 8 other tissues.

Summary

Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in ceramide metabolic process and oligosaccharide metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

FUT5 Products (1)

mRNA	Protein	Name
NM_002034.2	NP_002025.2	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	1740457	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	1740457	GOA
enables fucosyltransferase activity	IDA IDA: Inferred from direct assay	7721776	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	7721776	GOA
involved in oligosaccharide metabolic process	IDA IDA: Inferred from direct assay	1740457	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT5 Protein Structure

Glyco_transf_10

0
100
200
300
374 a.a.

Protein Preferred Names	Protein Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5

Related Diseases

Diseases	Alias
Drug-Induced Lupus Erythematosus	Dile Dil Drug-Induced Systemic Lupus Erythematosus
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05156	FUT5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown