2. Gene
  3. Alox5 - arachidonate 5-lipoxygenase Gene

Alox5 - arachidonate 5-lipoxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as LOX5A

Gene ID: 25290 | Gene type: protein coding

About Alox5

Primary_assembly 4: 149,531,515-149,578,743 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 221 orthologues, 6 paralogues and is associated with 55 phenotypes. Biased expression in Lung (RPKM 53.5), Heart (RPKM 25.7) and 9 other tissues.

Summary

Predicted to enable arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; and response to hyperoxia. Located in several cellular components, including dendrite; nuclear envelope; and sarcolemma. Used to study several diseases, including brain ischemia; hypertension (multiple); pleurisy; portal hypertension; and pulmonary edema. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox5 Products(1)

mRNA Protein Name
NM_012822.2 NP_036954.2 polyunsaturated fatty acid 5-lipoxygenase

Alox5 Protein Structure

PLAT_LOX

PLAT_LOX: cd01753 (1 - 114)

Lipoxygenase

Lipoxygenase: cl37981 (220 - 664)

  • 0
  • 200
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  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid 5-lipoxygenase

5 - Lipoxygenase

5-LO

5-lipoxygenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00620 ALOX5 Human Pre-designed siRNA Set A / Unkown
HY-RS00621 Alox5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00622 Alox5 Rat Pre-designed siRNA Set A / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A / Unkown
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox5 NCBI NCBI:240