Alox5 - arachidonate 5-lipoxygenase Gene

Also Known as LOX5A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25290

About Alox5

Primary_assembly 4: 149,531,515-149,578,743 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 221 orthologues, 6 paralogues and is associated with 55 phenotypes. Biased expression in Lung (RPKM 53.5), Heart (RPKM 25.7) and 9 other tissues.

Summary

Predicted to enable arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; and response to hyperoxia. Located in several cellular components, including dendrite; nuclear envelope; and sarcolemma. Used to study several diseases, including brain ischemia; hypertension (multiple); pleurisy; portal hypertension; and pulmonary edema. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox5 Products (1)

mRNA Protein Name
NM_012822.2 NP_036954.2 polyunsaturated fatty acid 5-lipoxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19075240 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
15107407 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
16331105 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
12490039 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16956363 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
16606359 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
16606359 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15107407 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox5 Protein Structure

PLAT_LOX

PLAT_LOX: cd01753 (1 - 114)

Lipoxygenase

Lipoxygenase: cl37981 (220 - 664)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid 5-lipoxygenase

  • 5 - Lipoxygenase

  • 5-LO

  • 5-lipoxygenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00620 ALOX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175634 ALOX5 stabilizer-1 / Unkown
HY-175634A ALOX5 stabilizer-1 TFA / Unkown
HY-E71028 5-Lipoxygenase, Human / Unkown
HY-RS00621 Alox5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00622 Alox5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox5 NCBI NCBI:240