Nr1d1 - nuclear receptor subfamily 1, group D, member 1 Gene

Also Known as REV-ERBAALPHA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 252917

Summary

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor Aryl Hydrocarbon Receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]

Nr1d1 Products (2)

mRNA Protein Name
NM_001113422.2 NP_001106893.2 nuclear receptor subfamily 1 group D member 1 isoform 1
NM_145775.3 NP_665718.2 nuclear receptor subfamily 1 group D member 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21874017 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
8474464 RGD
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
8015547 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
24144766 RGD
involved in photoperiodism IEP
IEP: Inferred from expression pattern
21076970 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22425774 RGD
involved in positive regulation of circadian rhythm IDA
IDA: Inferred from direct assay
18946026 RGD
involved in regulation of circadian rhythm IDA
IDA: Inferred from direct assay
22425774 RGD
involved in regulation of hepatic stellate cell activation IDA
IDA: Inferred from direct assay
24497272 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
21874017 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21874017 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 1 group D member 1

  • EAR-1

  • V-erbA-related protein 1

  • V-erbA-related protein EAR-1

  • rev-erb alpha

  • rev-erbA-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09527 NR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18073 Nr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24548 Nr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1d1 NCBI NCBI:9572