Slamf1 - signaling lymphocytic activation molecule family member 1 Gene

Also Known as Slam; CD150; IPO-3; CDw150; ESTM51; 4933415F16

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27218

Summary

Enables identical protein binding activity and signaling receptor activity. Involved in natural killer cell activation; positive regulation of activated T cell proliferation; and regulation of cytokine production. Acts upstream of or within several processes, including leukocyte chemotaxis involved in inflammatory response; positive regulation of leukocyte chemotaxis; and regulation of vesicle fusion. Located in external side of plasma membrane and phagocytic vesicle. Is expressed in liver lobe. Orthologous to human SLAMF1 (signaling lymphocytic activation molecule family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slamf1 Products (2)

mRNA	Protein	Name
NM_001360898.1	NP_001347827.1	signaling lymphocytic activation molecule isoform 2 precursor
NM_013730.4	NP_038758.2	signaling lymphocytic activation molecule isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	25799045	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10970095	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	25799045	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25799045	MGI
involved in natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	18031695	MGI
involved in natural killer cell proliferation	IMP IMP: Inferred from mutant phenotype	18031695	MGI
involved in negative regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	11477403	MGI
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	11477403	MGI
involved in positive regulation of T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	9126961	MGI
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	9126961	MGI
acts upstream of or within positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	25799045	MGI
acts upstream of or within positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	22960654	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	9126961	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	22493499	MGI
acts upstream of or within regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	22493499	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	22960654	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	18971422	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	22493499	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
signaling lymphocytic activation molecule	SLAM family member 1 signaling lymphocyte activation molecule

Slamf1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Slamf1	Q9QUM4	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	22493499
Intra	Slamf1	Q9QUM4	Fyn	Mus musculus	P39688	Pull Down	16847311
Intra	Slamf1	Q9QUM4	Fyn	Mus musculus	P39688	Anti Bait CoIP	16847311
Intra	Slamf1	Q9QUM4	Fyn	Mus musculus	P39688	Pull Down	11477403
Intra	Slamf1	Q9QUM4	Fyn	Mus musculus	P39688	Anti Bait CoIP	11477403
Intra	Slamf1	Q9QUM4	Fyn	Mus musculus	P39688	Pull Down	12545173
Intra	Slamf1	Q9QUM4	Sh2d1a	Mus musculus	O88890	Pull Down	12545173
Intra	Slamf1	Q9QUM4	Sh2d1a	Mus musculus	O88890	CoIP	11477403
Intra	Slamf1	Q9QUM4	Sh2d1a	Mus musculus	O88890	Anti Bait CoIP	16847311
Cross	Slamf1	Q9QUM4	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	22493499

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Slamf1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72467	CD150/SLAMF1 Protein, Mouse (HEK293, His)	Q9QUM4-1 (T25-P242)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12979	SLAMF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17619	Slamf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24079	Slamf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slamf1	NCBI	NCBI:6504