SPINK4 - serine peptidase inhibitor Kazal type 4 Gene

Also Known as PEC60; HEL136; PEC-60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27290

About SPINK4

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,240,167-33,248,567 (from NCBI)

This gene has 2 transcripts (splice variants) and 84 orthologues. Biased expression in colon (RPKM 295.5), small intestine (RPKM 212.3) and 2 other tissues.

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to xenobiotic stimulus. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

SPINK4 Products (1)

mRNA Protein Name
NM_014471.3 NP_055286.1 serine protease inhibitor Kazal-type 4 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINK4 Protein Structure

Kazal_1

Kazal_1: Kazal-type serine protease inhibitor domain (37 - 86)

  • 0
  • 86 a.a.
Protein Preferred Names Protein Names

serine protease inhibitor Kazal-type 4

  • epididymis luminal protein 136

SPINK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPINK4 O60575 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
SPINK4 O60575 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
SPINK4 O60575 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPINK4 Proteins

Cat. No. Product Name Accession Purity
HY-P71035 SPINK4 Protein, Human (HEK293, His) O60575 (G27-C86) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13681 SPINK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19815 Spink4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26311 Spink4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPINK4 RGD RGD:1303188
Macaca mulatta SPINK4 VGNC VGNC:84906
Bos taurus SPINK4 VGNC VGNC:55080
Canis familiaris SPINK4 VGNC VGNC:46744
Felis catus SPINK4 VGNC VGNC:102986
Mus musculus SPINK4 MGD MGI:1341848
Others SPINK4 NCBI