Gabra2 - gamma-aminobutyric acid type A receptor subunit alpha 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289606

Summary

Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Located in dendrite membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2). [provided by Alliance of Genome Resources, Apr 2022]

Gabra2 Products (1)

mRNA Protein Name
NM_001135779.3 NP_001129251.3 gamma-aminobutyric acid receptor subunit alpha-2 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
8876241 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
15620359 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
8876241 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11168550 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-2

  • GABA(A) receptor subunit alpha-2

  • gamma-aminobutyric acid (GABA) A receptor, alpha 2

  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2

  • gamma-aminobutyric acid receptor A2 subunit

  • gamma-aminobutyric acid type A receptor alpha2 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05210 GABRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20551 Gabra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27060 Gabra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra2 NCBI NCBI:2555