Polb - DNA polymerase beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29240

Summary

Enables DNA-directed DNA Polymerase activity; damaged DNA binding activity; and metal ion binding activity. Involved in several processes, including DNA repair; response to gamma radiation; and response to hyperoxia. Located in nucleus. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human POLB (DNA Polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]

Polb Products (1)

mRNA Protein Name
NM_017141.2 NP_058837.2 DNA polymerase beta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11330999 RGD
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
17412650 RGD
enables damaged DNA binding IDA
IDA: Inferred from direct assay
12388548 RGD
enables metal ion binding IDA
IDA: Inferred from direct assay
11330999 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11734998 RGD
Biological Process GO Annotation Evidence References Source
involved in base-excision repair, gap-filling IDA
IDA: Inferred from direct assay
17412650 RGD
involved in pyrimidine dimer repair IDA
IDA: Inferred from direct assay
12388548 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18259862 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
12425958 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
8786668 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase beta

  • DNA pol beta

  • DNA-directed DNA polymerase beta

  • polymerase (DNA directed), beta

  • polymerase (DNA) beta

  • polymerase-beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10818 POLB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19369 Polb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25861 Polb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polb NCBI NCBI:5423